| Gene Symbol |
PURB
|
| Entrez Gene |
5814
|
| Alt Symbol |
PURBETA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
purine-rich element binding protein B
|
| Other Description |
purine-rich element-binding protein B|transcriptional activator protein Pur-beta
|
| Swissprots |
Q96QR8 A4D2L7
|
| Accessions |
AAS00366 EAL23749 EAW61073 Q96QR8 AA016115 AI042138 AI050971 AI209043 AI912557 AK054977 AK056651 AK057669 AL119133 AL705373 AY039216 AAK72462 BC101735 AAI01736 BC101737 AAI01738 BF964815 BG776957 BM015566 BQ890213 BU154650 BU177276 CB046374 DR005180 R89560 NM_033224 NP_150093
|
| Function |
Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:1448097}.
|
| Tissue Specificity |
Expressed in myocardium of heart failure patients. {ECO:0000269|PubMed:12933792}.
|