PURB

Gene Symbol	PURB
Entrez Gene	5814
Alt Symbol	PURBETA
Species	Human
Gene Type	protein-coding
Description	purine-rich element binding protein B
Other Description	purine-rich element-binding protein B|transcriptional activator protein Pur-beta
Swissprots	Q96QR8 A4D2L7
Accessions	AAS00366 EAL23749 EAW61073 Q96QR8 AA016115 AI042138 AI050971 AI209043 AI912557 AK054977 AK056651 AK057669 AL119133 AL705373 AY039216 AAK72462 BC101735 AAI01736 BC101737 AAI01738 BF964815 BG776957 BM015566 BQ890213 BU154650 BU177276 CB046374 DR005180 R89560 NM_033224 NP_150093
Function	Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:1448097}.
Tissue Specificity	Expressed in myocardium of heart failure patients. {ECO:0000269|PubMed:12933792}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Purβ siRNA (h) - sc-89882 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Purβ shRNA Plasmid (h) - sc-89882-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Purβ shRNA (h) Lentiviral Particles - sc-89882-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN17738 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17738 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PURB siRNA (Human) - CRH3930 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PURB (NM_033224.3) - SHH387056 from Creative biogene Category siRNA Species Reactivities Human

Human PURB siRNA - orb264432 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PURB shRNA Plasmid (Human) - CHH3930 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PURB miRNA 3'UTR clone - MiUTR1H-08494 from Creative biogene Species Reactivities Human

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