| Gene Symbol |
PSMG2
|
| Entrez Gene |
56984
|
| Alt Symbol |
CLAST3, HCCA3, HsT1707, MDS003, PAC2, TNFSF5IP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) assembly chaperone 2
|
| Other Description |
CD40 ligand-activated specific transcript 3|HDCMC29P|HSPC260|PAC-2|hepatocellular carcinoma susceptibility protein|hepatocellular carcinoma-susceptibility protein 3|likely ortholog of mouse CD40 ligand-activated specific transcript 3 (Clast3)|proteasome assembling chaperone 2|proteasome assembly chaperone 2|tumor necrosis factor superfamily member 5-induced protein 1|tumor necrosis factor superfamily, member 5-induced protein 1|x 003 protein
|
| Swissprots |
Q969U7 V9GYH7 B0YJB3 Q9NRV1 Q6IAH4
|
| Accessions |
ACA06090 EAX01540 EAX01541 EAX01542 Q969U7 AF068295 AAF65184 AF161378 AAF28938 AF168712 AAF87314 AF276707 AAK69439 AK025410 AK057005 BAG51841 AK225882 BC013356 AAH13356 BF668035 BR000237 FAA00023 CR457181 CAG33462 HQ447389 ADQ31875 NM_020232 NP_064617 NM_147163 NP_671692
|
| Function |
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:Q9EST4}.
|
| Tissue Specificity |
Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue. {ECO:0000269|PubMed:11854909}.
|