DYRK1A

Gene Symbol DYRK1A
Entrez Gene 1859
Alt Symbol DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Species Human
Gene Type protein-coding
Description dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Other Description MNB/DYRK protein kinase|dual specificity YAK1-related kinase|dual specificity tyrosine-phosphorylation-regulated kinase 1A|hMNB|mnb protein kinase homolog hp86|protein kinase minibrain homolog|serine/threonine kinase MNB|serine/threonine-specific protein kinase
Swissprots Q92810 O60769 Q92582 Q9UNM5 Q13627
Accessions EAX09702 EAX09703 EAX09704 EAX09705 EAX09706 EAX09707 EAX09708 Q13627 AB015282 BAA33975 AB015283 BAA33976 AB015284 BAA33977 AF108830 AAD31169 AJ001870 CAA05059 AJ001871 CAA05060 AK301752 BAG63214 BC030515 BC045802 BC065184 BC156309 AAI56310 BC172505 AAI72505 D85759 BAA12866 D86550 BAA13110 HF584751 CCQ44048 HF584752 CCQ44049 U52373 AAB18639 U58496 AAC50939 Z25423 CAA80910 XM_005260931 XP_005260988 XM_005260933 XP_005260990 XM_006723976 XP_006724039 XM_006723977 XP_006724040 XM_006723978 XP_006724041 XM_006723979 XP_006724042 XM_011529482 XP_011527784 XM_011529483 XP_011527785 XM_011529484 XP_011527786 XM_011529485 XP_011527787 NM_001396 NP_001387 NM_101395 NP_567824 NM_130436 NP_569120 NM_130438 NP_569122 NM_130437
Function May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3. {ECO:0000250, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.
Subcellular Location Nucleus speckle.
Tissue Specificity Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. {ECO:0000269|PubMed:10329007, ECO:0000269|PubMed:8769099, ECO:0000269|PubMed:8872470, ECO:0000269|PubMed:8975710}.

DYRK1A Antibody - 2771 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SY-SY5Y and PC3 cells using DYRK1A Antibody.

DYRK1A (D30C10) Rabbit mAb - 8765 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D30C10
Western blot analysis of extracts from HeLa cells and mouse brain using DYRK1A (D30C10) Rabbit mAb.

Dyrk1A (H-143) - sc-28899 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dyrk1A (H-143): sc-28899. Western blot analysis of Dyrk1A expression in HL-60 (A) and SH-SY5Y (B) whole cell lysates.

Dyrk1A (A-16) - sc-12571 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dyrk1A (A-16): sc-12571. Western blot analysis of Dyrk1A expression in PC-3 whole cell lysate.

Dyrk1A (G-19) - sc-12568 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dyrk1A (G-19): sc-12568. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic and membrane staining of trophoblastic cells and cytoplasmic and nuclear staining of decidual cells.

Dyrk1A (RR.7) - sc-100376 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Dyrk1A (RR.7): sc-100376. Western blot analysis of Dyrk1A expression in HeLa nuclear extract.

Dyrk1A (S-21) - sc-130741 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Dyrk1A (S-21): sc-130741. Western blot analysis of Dyrk1A expression in HL-60 whole cell lysate.

Anti-DYRK1A antibody - ab65220 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab65220, at a 1/500 dilution, staining DYRK1A in HepG2 cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Anti-DYRK1A antibody - ab69811 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DYRK1A antibody (ab69811) at 1/1000 dilution + 30µg of HeLa whole cell lysateSecondaryDonkey anti-Rabbit conjugated to HRP at 1/5000 dilution

Anti-DYRK1A antibody - ab54944 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DYRK1A antibody - ab16140 from Abcam

Prices $372.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-DYRK1A antibody - ab156818 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-DYRK1A antibody (ab156818) at 0.5 µg/ml + K562 cell line lysate at 35 µgdeveloped using the ECL technique

Anti-DYRK1A antibody - ab53231 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK1A antibody - Aminoterminal end - ab71464 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DYRK1A antibody - Aminoterminal end (ab71464) at 1/60 dilution + 293 cell line lysates at 35 µg

Anti-DYRK1A antibody - C-terminal - ab180910 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-DYRK1A antibody - C-terminal (ab180910) at 1 µg/mlLane 2 : Anti-DYRK1A antibody - C-terminal (ab180910) at 2 µg/mlLane 1 : HeLa cell lysateLane 2 : HeLa cell lysateLysates/proteins at 15 µg per lane.

Anti-DYRK1A antibody - C-terminal - ab174483 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DYRK1A antibody - C-terminal (ab174483) at 1/100 dilution + NCI-H460 cell line lysate at 35 µg

Anti-DYRK / DYRK1A Antibody (aa674-763) - LS-C124944 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DYRK / DYRK1A Antibody (aa107-156) - LS-C111065 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DYRK1A antibody LS-C111065 Western blot of ACHN lysate.

Anti-DYRK / DYRK1A Antibody (aa486-763) - LS-C26589 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
Immunoprecipitation of Dyrk from 293T transfected cells. Immunoprecipitation with - 1) control Ab, 2) Anti-MNP 2 ug/ml, 3) anti-Dyrk 2 ug/ml, 4) anti-Dyrk 10 ug/ml, 5) competitor?s anti-Dyrk Ab 10 ug/ml, Western blot performed with anti-Dyrk Ab at 2 ug/ml.

Anti-DYRK / DYRK1A Antibody (aa389-418) - LS-C98732 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of DYRK1A Antibody polyclonal antibody in HL60 cell line lysates (35 ug/lane). DYRK1A (arrow) was detected using the purified antibody.

Anti-DYRK / DYRK1A Antibody - LS-C144662 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK / DYRK1A Antibody (aa107-136) - LS-C98731 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DYRK1A Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-DYRK / DYRK1A Antibody (aa21-70) - LS-C119030 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HepG2 cells, using DYR1A Antibody. The picture on the right is treated with the synthesized peptide.

Anti-DYRK / DYRK1A Antibody (aa718-745, AP) - LS-C256393 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK / DYRK1A Antibody (aa718-745, Biotin) - LS-C256395 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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