DYRK1A

Gene Symbol	DYRK1A
Entrez Gene	1859
Alt Symbol	DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Species	Human
Gene Type	protein-coding
Description	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Other Description	MNB/DYRK protein kinase|dual specificity YAK1-related kinase|dual specificity tyrosine-phosphorylation-regulated kinase 1A|hMNB|mnb protein kinase homolog hp86|protein kinase minibrain homolog|serine/threonine kinase MNB|serine/threonine-specific protein kinase
Swissprots	Q92810 O60769 Q92582 Q9UNM5 Q13627
Accessions	EAX09702 EAX09703 EAX09704 EAX09705 EAX09706 EAX09707 EAX09708 Q13627 AB015282 BAA33975 AB015283 BAA33976 AB015284 BAA33977 AF108830 AAD31169 AJ001870 CAA05059 AJ001871 CAA05060 AK301752 BAG63214 BC030515 BC045802 BC065184 BC156309 AAI56310 BC172505 AAI72505 D85759 BAA12866 D86550 BAA13110 HF584751 CCQ44048 HF584752 CCQ44049 U52373 AAB18639 U58496 AAC50939 Z25423 CAA80910 XM_005260931 XP_005260988 XM_005260933 XP_005260990 XM_006723976 XP_006724039 XM_006723977 XP_006724040 XM_006723978 XP_006724041 XM_006723979 XP_006724042 XM_011529482 XP_011527784 XM_011529483 XP_011527785 XM_011529484 XP_011527786 XM_011529485 XP_011527787 NM_001396 NP_001387 NM_101395 NP_567824 NM_130436 NP_569120 NM_130438 NP_569122 NM_130437
Function	May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3. {ECO:0000250, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.
Subcellular Location	Nucleus speckle.
Tissue Specificity	Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. {ECO:0000269|PubMed:10329007, ECO:0000269|PubMed:8769099, ECO:0000269|PubMed:8872470, ECO:0000269|PubMed:8975710}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat DYRK / DYRK1A ELISA Kit (Cell-Based ELISA) - LS-F3186 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse DYRK / DYRK1A ELISA Kit (Sandwich ELISA) - LS-F7258 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.063 ng/ml Range 0.156-10 ng/ml

Human DYRK / DYRK1A ELISA Kit (Sandwich ELISA) - LS-F8931 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.156-10 ng/ml

Human DYRK1A ELISA Kit - abx151361 from Abbexa Category ELISA Kit Sensitivity 0.117 ng/ml Range 0.313 ng/ml - 20 ng/ml

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A), Human, ELISA Kit - SEJ193Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.117ng/mL Range 0.312-20ng/mL

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A), ELISA Kit - MBS2019349 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.063ng/mL. Range 0.156-10ng/mL

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A), ELISA Kit - MBS2019821 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.117ng/mL. Range 0.313-20ng/mL

Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ELISA Kit - MBS283002 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DYR1A Colorimetric Cell-Based ELISA - CB5998 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

ELISA Kit for Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) - SEJ193Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) - SEJ193Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.063ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A) - SEJ193Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A), Human, ELISA Kit - DL-DYRK1A-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human DYRK1A ELISA Kit - abx573004 from Abbexa Category ELISA Kit Sensitivity 0.117 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human DYRK1A ELISA Kit - E012474 from Biobool Category ELISA Kit Sensitivity Typically less than 0.117ng/mL.

DYRK1A ELISA Kit (Human) (OKCD01050) - OKCD01050 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.117 ng/mL Range 0.312-20 ng/mL

Human Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) ELISA Kit - AE58865HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.117 ng/mL Range 0.312-20 ng/mL

Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A), ELISA Kit - MBS453769 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.117ng/mL Range 0.312-20ng/mL

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