| Gene Symbol |
DYRK1A
|
| Entrez Gene |
1859
|
| Alt Symbol |
DYRK, DYRK1, HP86, MNB, MNBH, MRD7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
|
| Other Description |
MNB/DYRK protein kinase|dual specificity YAK1-related kinase|dual specificity tyrosine-phosphorylation-regulated kinase 1A|hMNB|mnb protein kinase homolog hp86|protein kinase minibrain homolog|serine/threonine kinase MNB|serine/threonine-specific protein kinase
|
| Swissprots |
Q92810 O60769 Q92582 Q9UNM5 Q13627
|
| Accessions |
EAX09702 EAX09703 EAX09704 EAX09705 EAX09706 EAX09707 EAX09708 Q13627 AB015282 BAA33975 AB015283 BAA33976 AB015284 BAA33977 AF108830 AAD31169 AJ001870 CAA05059 AJ001871 CAA05060 AK301752 BAG63214 BC030515 BC045802 BC065184 BC156309 AAI56310 BC172505 AAI72505 D85759 BAA12866 D86550 BAA13110 HF584751 CCQ44048 HF584752 CCQ44049 U52373 AAB18639 U58496 AAC50939 Z25423 CAA80910 XM_005260931 XP_005260988 XM_005260933 XP_005260990 XM_006723976 XP_006724039 XM_006723977 XP_006724040 XM_006723978 XP_006724041 XM_006723979 XP_006724042 XM_011529482 XP_011527784 XM_011529483 XP_011527785 XM_011529484 XP_011527786 XM_011529485 XP_011527787 NM_001396 NP_001387 NM_101395 NP_567824 NM_130436 NP_569120 NM_130438 NP_569122 NM_130437
|
| Function |
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3. {ECO:0000250, ECO:0000269|PubMed:20981014, ECO:0000269|PubMed:21127067, ECO:0000269|PubMed:23665168, ECO:0000269|PubMed:8769099}.
|
| Subcellular Location |
Nucleus speckle.
|
| Tissue Specificity |
Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. {ECO:0000269|PubMed:10329007, ECO:0000269|PubMed:8769099, ECO:0000269|PubMed:8872470, ECO:0000269|PubMed:8975710}.
|