| Gene Symbol |
CELF6
|
| Entrez Gene |
60677
|
| Alt Symbol |
BRUNOL6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CUGBP, Elav-like family member 6
|
| Other Description |
Bruno -like 6, RNA binding protein|CELF-6|CUG-BP and ETR-3 like factor 6|CUG-BP- and ETR-3-like factor 6|CUGBP Elav-like family member 6|RNA-binding protein BRUNOL-6|bruno-like 6, RNA binding protein|bruno-like protein 6
|
| Swissprots |
Q6ZNJ7 B4DJB6 B4DG28 Q6PII4 Q8N607 Q96J87
|
| Accessions |
EAW77900 EAW77901 Q96J87 AF401233 AAK95615 AF425606 AAL34513 AK124858 BAG54108 AK131098 BAC85148 AK294382 BAG57639 AK296004 BAG58778 BC030835 AAH30835 BC033838 AAH33838 BM681937 BM930660 BU732838 CA393931 DC368992 NM_001172684 NP_001166155 NM_001172685 NP_001166156 NM_052840 NP_443072
|
| Function |
RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA. {ECO:0000269|PubMed:14761971}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Expressed mainly in kidney, brain and testis and present in other tissues albeit at lower levels. Also expressed in fetal kidney. {ECO:0000269|PubMed:14761971}.
|