Gene Symbol | CELF6 |
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Entrez Gene | 60677 |
Alt Symbol | BRUNOL6 |
Species | Human |
Gene Type | protein-coding |
Description | CUGBP, Elav-like family member 6 |
Other Description | Bruno -like 6, RNA binding protein|CELF-6|CUG-BP and ETR-3 like factor 6|CUG-BP- and ETR-3-like factor 6|CUGBP Elav-like family member 6|RNA-binding protein BRUNOL-6|bruno-like 6, RNA binding protein|bruno-like protein 6 |
Swissprots | Q6ZNJ7 B4DJB6 B4DG28 Q6PII4 Q8N607 Q96J87 |
Accessions | EAW77900 EAW77901 Q96J87 AF401233 AAK95615 AF425606 AAL34513 AK124858 BAG54108 AK131098 BAC85148 AK294382 BAG57639 AK296004 BAG58778 BC030835 AAH30835 BC033838 AAH33838 BM681937 BM930660 BU732838 CA393931 DC368992 NM_001172684 NP_001166155 NM_001172685 NP_001166156 NM_052840 NP_443072 |
Function | RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA. {ECO:0000269|PubMed:14761971}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. |
Tissue Specificity | Expressed mainly in kidney, brain and testis and present in other tissues albeit at lower levels. Also expressed in fetal kidney. {ECO:0000269|PubMed:14761971}. |
CELF6 CRISPR/Cas9 KO Plasmid (h) - sc-418557 from Santa Cruz Biotechnology
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CELF6 HDR Plasmid (h) - sc-418557-HDR from Santa Cruz Biotechnology
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CELF6 Double Nickase Plasmid (h) - sc-418557-NIC from Santa Cruz Biotechnology
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CELF6 Double Nickase Plasmid (h2) - sc-418557-NIC-2 from Santa Cruz Biotechnology
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CELF6 CRISPR Activation Plasmid (h) - sc-418557-ACT from Santa Cruz Biotechnology
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CELF6 CRISPR Activation Plasmid (h2) - sc-418557-ACT-2 from Santa Cruz Biotechnology
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CELF6 Lentiviral Activation Particles (h) - sc-418557-LAC from Santa Cruz Biotechnology
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CELF6 Lentiviral Activation Particles (h2) - sc-418557-LAC-2 from Santa Cruz Biotechnology
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CELF6 siRNA (h) - sc-90308 from Santa Cruz Biotechnology
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CELF6 shRNA Plasmid (h) - sc-90308-SH from Santa Cruz Biotechnology
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CELF6 shRNA (h) Lentiviral Particles - sc-90308-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN5930 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5930 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10103 from Sigma-Aldrich
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CELF6 siRNA (Human) - CRJ1827 from Cohesion Biosciences
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BRUNOL6 RNAi - H00060677-R01 from Novus Biologicals
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CELF6 - MBS8223904 from MyBioSource
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shRNA set against Human CELF6 (NM_052840.4) - SHH261517 from Creative biogene
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Human CELF6 siRNA - orb272328 from Biorbyt
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CELF6 shRNA Plasmid (Human) - CHJ1827 from Cohesion Biosciences
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CELF6 miRNA 3'UTR clone - MiUTR3H-12545 from Creative biogene
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