Gene Symbol | SERPINB7 |
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Entrez Gene | 8710 |
Alt Symbol | MEGSIN, PPKN, TP55 |
Species | Human |
Gene Type | protein-coding |
Description | serpin peptidase inhibitor, clade B (ovalbumin), member 7 |
Other Description | mesangium predominant gene, megsin|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7|serpin B7 |
Swissprots | O75635 F5GZC0 Q3KPG4 B4DUW8 Q1ED45 |
Accessions | EAW63159 O75635 AF027866 AAC64506 AK290673 BAF83362 AK290876 BAF83565 AK300828 BAG62480 BC069417 AAH69417 BC069442 AAH69442 BC069547 AAH69547 BC106743 AAI06744 BC106744 AAI06745 BP332064 BX641156 CAE46069 CD701612 CD702645 D88575 BAA31232 DA577978 XM_006722562 XP_006722625 XM_011526236 XP_011524538 NM_001040147 NP_001035237 NM_001261830 NP_001248759 NM_001261831 NP_001248760 NM_003784 NP_003775 |
Function | Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Predominantly expressed in mesangial cells. Expressed in the epidermis of the whole body. {ECO:0000269|PubMed:24207119}. |
megsin CRISPR/Cas9 KO Plasmid (h) - sc-418593 from Santa Cruz Biotechnology
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megsin HDR Plasmid (h) - sc-418593-HDR from Santa Cruz Biotechnology
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megsin Double Nickase Plasmid (h) - sc-418593-NIC from Santa Cruz Biotechnology
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megsin Double Nickase Plasmid (h2) - sc-418593-NIC-2 from Santa Cruz Biotechnology
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megsin CRISPR Activation Plasmid (h) - sc-418593-ACT from Santa Cruz Biotechnology
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megsin CRISPR Activation Plasmid (h2) - sc-418593-ACT-2 from Santa Cruz Biotechnology
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megsin Lentiviral Activation Particles (h) - sc-418593-LAC from Santa Cruz Biotechnology
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megsin Lentiviral Activation Particles (h2) - sc-418593-LAC-2 from Santa Cruz Biotechnology
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megsin siRNA (h) - sc-75768 from Santa Cruz Biotechnology
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megsin shRNA Plasmid (h) - sc-75768-SH from Santa Cruz Biotechnology
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megsin shRNA (h) Lentiviral Particles - sc-75768-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU059451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19147 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19147 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06145 from Sigma-Aldrich
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SERPINB7 siRNA (Human) - CRH5733 from Cohesion Biosciences
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SERPINB7 - MBS8206499 from MyBioSource
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shRNA set against Human Serpinb7 (NM_003784.3) - SHH405264 from Creative biogene
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SERPINB7 shRNA Plasmid (Human) - CHH5733 from Cohesion Biosciences
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SERPINB7 miRNA 3'UTR clone - MiUTR4H-TG07954 from Creative biogene
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