PDE9A

Gene Symbol PDE9A
Entrez Gene 5152
Alt Symbol HSPDE9A2
Species Human
Gene Type protein-coding
Description phosphodiesterase 9A
Other Description CGMP-specific 3',5'-cyclic phosphodiesterase type 9|high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A|phosphodiesterase PDE9A21
Swissprots Q86WN4 Q5QD39 B2RBI5 Q86WP0 O75490 Q86WN6 Q86WN3 Q86WN9 Q86SJ3 Q86WN8 O75491 O76083 D3DSJ9 Q86WN5 Q86WN7 Q86SI6 D3DSJ8 Q86SF7 O95225 Q53Y40 B4DFI5
Accessions BAA88847 BAA95552 EAX09531 EAX09532 EAX09533 EAX09534 EAX09535 EAX09536 EAX09537 EAX09538 EAX09539 EAX09540 EAX09541 EAX09542 EAX09543 EAX09544 EAX09545 EAX09546 EAX09547 EAX09548 EAX09549 O76083 AF048837 AAC39778 AF067223 AAC26723 AF067224 AAC26724 AF067225 AAC26725 AF067226 AAC26726 AI492065 AK001165 AK001307 AK074662 BAC11120 AK127770 AK294112 BAG57446 AK308753 AK314679 BAG37232 AY196299 AAO34685 AY196300 AAO34686 AY196301 AAO34687 AY196302 AAO34688 AY196303 AAO34689 AY196304 AAO34690 AY196305 AAO34691 AY196306 AAO34692 AY196307 AAO34693 AY196308 AAO34694 AY196309 AAO34695 AY196310 AAO34696 AY196311 AAO34697 AY196312 AAO34698 AY196313 AAO34699 AY196314 AAO34700 AY242121 AAO88210 AY701187 AAV84271 BC009047 AAH09047 BT007016 AAP35662 GQ129331 ACT64465 GQ129332 ACT64466 XM_011529597 XP_011527899 XM_011529598 XP_011527900 XM_011529599 XP_011527901 XM_011529600 XP_011527902 XM_011529601 XP_011527903 XR_937502 NM_001001567 NP_001001567 NM_001001568 NP_001001568 NM_001001569 NP_001001569 NM_001001570 NP_001001570 NM_001001571 NP_001001571 NM_001001572 NP_001001572 NM_001001573 NP_001001573 NM_001001574 NP_001001574 NM_001001575 NP_001001575 NM_001001576 NP_001001576 NM_001001577 NP_001001577 NM_001001578 NP_001001578 NM_001001579 NP_001001579 NM_001001580 NP_001001580 NM_001001581 NP_001001581 NM_001001582 NP_001001582 NM_001001583 NP_001001583 NM_001001584 NP_001001584 NM_001001585 NP_001001585 NM_002606 NP_002597
Function Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:18757755}.
Subcellular Location Isoform PDE9A3: Cytoplasm. Endoplasmic reticulum.
Tissue Specificity Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate. {ECO:0000269|PubMed:12565835}.
Top Pathways Purine metabolism

PDE9A (D-16) - sc-50267 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDE9A (D-16): sc-50267. Western blot analysis of PDE9A expression in non-transfected: sc-110760 (A) and truncated human PDE9A transfected: sc-111170 (B) 293 whole cell lysates.

PDE9A (D-7) - sc-376271 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDE9A (D-7): sc-376271. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of glandular cells.

PDE9A (E-2) - sc-271754 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDE9A (E-2): sc-271754. Western blot analysis of PDE9A expression in non-transfected: sc-110760 (A) and human PDE9A transfected: sc-158830 (B) 293 whole cell lysates.

PDE9A (H-170) - sc-99221 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDE9A (H-170): sc-99221. Western blot analysis of PDE9A expression in non-transfected: sc-110760 (A) and human PDE9A transfected: sc-158830 (B) 293 whole cell lysates and mouse spleen tissue extract (C).

PDE9A (G-4) - sc-166375 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDE9A (G-4): sc-166375. Western blot analysis of PDE9A expression in non-transfected: sc-110760 (A) and human PDE9A transfected: sc-111170 (B) 293 whole cell lysates.

PDE9A (I-17) - sc-50268 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDE9A (I-17): sc-50268. Western blot analysis of PDE9A expression in non-transfected: sc-110760 (A) and truncated human PDE9A transfected: sc-111170 (B) 293 whole cell lysates.

PDE9A (S-19) - sc-50269 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDE9A (S-19): sc-50269. Western blot analysis of PDE9A expression in mouse spleen tissue extract.

PDE9A (T-19) - sc-50270 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDE9A (T-19): sc-50270. Western blot analysis of PDE9A expression in non-transfected: sc-110760 (A) and truncated human PDE9A transfected: sc-111170 (B) 293 whole cell lysates.

Anti-PDE9A antibody - ab118378 from Abcam

Host Mouse
Clonality Monoclonal
ab118378, at 3ug/ml, staining PDE9A in Formalin-fixed, Paraffin-embedded Human brain cerebellum tissue by Immunohistochemistry.

Anti-PDE9A antibody - ab125672 from Abcam

Prices $428.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDE9A antibody (ab125672) at 1/2000 dilutionLane 1 : Insect cells, transfected with Human PDE1A3Lane 2 : Insect cells transfected with Human PDE2A3Lane 3 : Insect cells, transfected with Human PDE3ALane 4 : Insect cells, transfected with Human PDE4A1Lane 5 : Insect cells, transfected with Human PDE5A2Lane 6 : Insect cells, transfected with Human PDE7ALane 7 : Insect cells, transfected with Human PDE8A1Lane 8 : Insect cells, transfected with Human PDE8BLane 9 : Insect cells transfected with Human PDE9A2Lane 10 : Insect cells, transfected with Human PDE10A1Lane 11 : Insect cells, transfected with Human PDE11A1developed using the ECL technique

Anti-PDE9A antibody - ab14625 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE9A antibody - ab168432 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells labeling PDE9A with ab168432 at 10&microg/ml.

Anti-PDE9A antibody - ab97556 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PDE9A antibody (ab97556) at 1/3000 dilution + 293T whole cell lysate at 30 µg

Anti-PDE9A antibody [1E1] - ab122981 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1E1
Immunohistochemistry of Formalin-Fixed, Paraffin-Embedded Human Adrenal Cortex tissue with ab122981 at 5ug/ml.

Anti-PDE9A Antibody (DY488) - LS-C181380 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE9A Antibody (DY650) - LS-C181379 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE9A Antibody (Biotin) - LS-C181378 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE9A Antibody (DY550) - LS-C181382 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE9A Antibody (HRP) - LS-C181381 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE9A Antibody (C-Terminus) - LS-C82355 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western blot of PDE9A antibody (1:2,000) against lysate from Insect cells transfected with the indicated human PDE isoform.

Anti-PDE9A Antibody (aa136-185) - LS-C80768 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PDE9A antibody LS-C80768 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-PDE9A Antibody (clone 1E1) IHC-plus™ - LS-B5937 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1E1
Anti-PDE9A antibody IHC of human prostate, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5937 concentration 5 ug/ml.

Anti-PDE9A Antibody (Internal) IHC-plus™ - LS-A713 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PDE9A antibody LS-A713 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PDE9A Antibody (aa1-216) - LS-C186027 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded N87 xenograft using PDE9A antibody at 1:500 dilution.

PDE9A Antibody - NBP1-00641 from Novus Biologicals

Prices $129.00, $299.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PDE9A Antibody [NBP1-00641] - WB analysis of PDE9A in HeLa whole cell lysate.
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