| Gene Symbol |
CHMP3
|
| Entrez Gene |
51652
|
| Alt Symbol |
CGI-149, NEDF, VPS24
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
charged multivesicular body protein 3
|
| Other Description |
25.1 protein|CHMP family, member 3|chromatin-modifying protein 3|neuroendocrine differentiation factor|vacuolar protein sorting 24 homolog|vacuolar protein sorting-associated protein 24
|
| Swissprots |
Q3ZTS9 Q53SU5 Q9Y3E7 B4DG34 B8ZZX5 Q9NZ51 A8K3W0 B8ZZM0 Q53S71
|
| Accessions |
AAX93078 AAY24211 EAW99448 EAW99449 EAW99450 EAW99451 EAW99452 Q9Y3E7 AF151907 AAD34144 AF219226 AAF26737 AK025046 AK025260 AK095433 AK129502 AK290725 BAF83414 AK312353 BAG35273 AK315835 BAF98726 AY364249 AAQ76808 BC004419 AAH04419 BG705423 BI562428 BU192410 DA046087 DA290886 EU446807 ABZ92336 NM_001005753 NP_001005753 NM_001193517 NP_001180446 NM_016079 NP_057163 NR_036454
|
| Function |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
|
| Subcellular Location |
Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane {ECO:0000305}. Note=Localizes to the midbody of dividing cells.
|
| Tissue Specificity |
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:15632132}.
|
| Top Pathways |
Endocytosis
|