CHMP3

Gene Symbol CHMP3
Entrez Gene 51652
Alt Symbol CGI-149, NEDF, VPS24
Species Human
Gene Type protein-coding
Description charged multivesicular body protein 3
Other Description 25.1 protein|CHMP family, member 3|chromatin-modifying protein 3|neuroendocrine differentiation factor|vacuolar protein sorting 24 homolog|vacuolar protein sorting-associated protein 24
Swissprots Q3ZTS9 Q53SU5 Q9Y3E7 B4DG34 B8ZZX5 Q9NZ51 A8K3W0 B8ZZM0 Q53S71
Accessions AAX93078 AAY24211 EAW99448 EAW99449 EAW99450 EAW99451 EAW99452 Q9Y3E7 AF151907 AAD34144 AF219226 AAF26737 AK025046 AK025260 AK095433 AK129502 AK290725 BAF83414 AK312353 BAG35273 AK315835 BAF98726 AY364249 AAQ76808 BC004419 AAH04419 BG705423 BI562428 BU192410 DA046087 DA290886 EU446807 ABZ92336 NM_001005753 NP_001005753 NM_001193517 NP_001180446 NM_016079 NP_057163 NR_036454
Function Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane {ECO:0000305}. Note=Localizes to the midbody of dividing cells.
Tissue Specificity Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:15632132}.
Top Pathways Endocytosis

CHMP3 (A-7) - sc-393817 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CHMP3 (A-7): sc-393817. Western blot analysis of CHMP3 expression in non-transfected: sc-117752 (A) and mouse CHMP3 transfected: sc-119240 (B) 293T whole cell lysates.

CHMP3 (C-1) - sc-393541 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CHMP3 (C-1): sc-393541. Western blot analysis of CHMP3 expression in non-transfected 293T: sc-117752 (A), mouse CHMP3 transfected 293T: sc-119240 (B) and Hep G2 (C) whole cell lysates.

CHMP3 (A-15) - sc-49909 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CHMP3 (A-15): sc-49909. Western blot analysis of CHMP3 expression in non-transfected: sc-117752 (A) and mouse CHMP3 transfected: sc-119240 (B) 293T whole cell lysates.

CHMP3 (C-6) - sc-271501 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CHMP3 (C-6): sc-271501. Western blot analysis of CHMP3 expression in non-transfected: sc-117752 (A) and mouse CHMP3 transfected: sc-119240 (B) 293T whole cell lysates.

CHMP3 (C-12) - sc-49910 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CHMP3 (C-12): sc-49910. Western blot analysis of CHMP3 expression in mouse pancreas tissue extract.

CHMP3 (E-16) - sc-49911 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CHMP3 (E-16): sc-49911. Western blot analysis of CHMP3 expression in non-transfected: sc-117752 (A) and mouse CHMP3 transfected: sc-119240 (B) 293T whole cell lysates.

CHMP3 (F-1) - sc-166361 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CHMP3 (F-1): sc-166361. Western blot analysis of CHMP3 expression in non-transfected: sc-117752 (A) and mouse CHMP3 transfected: sc-119240 (B) 293T whole cell lysates.

CHMP3 (FL-222) - sc-67228 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CHMP3 (FL-222): sc-67228. Western blot analysis of CHMP3 expression in non-transfected: sc-117752 (A) and mouse CHMP3 transfected: sc-119240 (B) 293T whole cell lysates.

CHMP3 (L-18) - sc-49912 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CHMP3 (L-18): sc-49912. Western blot analysis of CHMP3 expression in 3T3-L1 whole cell lysate.

Anti-VPS24 antibody - ab76333 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-VPS24 antibody (ab76333) at 1/1000 dilutionLane 1 : Rat Brain lysatesLane 2 : Rat Brain lysates + ab76333 pre-absorbed with immunizing peptidePerformed under reducing conditions.

Anti-VPS24 antibody - ab81054 from Abcam

Host Sheep
Clonality Polyclonal

Anti-VPS24 antibody - ab181680 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VPS24 antibody [EPR12821] - ab175930 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12821
Immunohistochemical analysis of paraffin-embedded human prostate tissue labeling VPS24 with ab175930 at 1/50 dilution

Anti-NEDF / VPS24 Antibody (N-Terminus) - LS-C94080 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-NEDF / VPS24 Antibody (N-Terminus) - LS-C94086 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-NEDF / VPS24 Antibody (Internal) - LS-C153394 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NEDF / VPS24 Antibody (aa28-77) - LS-C29868 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-NEDF / VPS24 Antibody (Internal) IHC-plus™ - LS-B7536 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-VPS24 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7536 concentration 10 ug/ml.

VPS24 Antibody - NBP1-20268 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

VPS24 Antibody - NBP1-30773 from Novus Biologicals

Prices $299.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

VPS24 Antibody - NBP1-03387 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: VPS24 Antibody [NBP1-03387] - WB on rat brain lysate using Rabbit antibody to n-terminal of CHMP3 (Charged multivesicular body protein 3, VPS24): whole serum at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the detected band.

Anti-CHMP3 antibody produced in rabbit - HPA015673 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-VPS24: <B>Cat. No. HPA015673</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon shows strong cytoplasmic positivity in glandular cells.

Anti-VPS24 antibody produced in rabbit - AV34452 from Sigma-Aldrich

Prices $347.50, $347.50
Sizes 50 µg, 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: HepG2 (<B>Cat. No. AV34452</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 0.5 μg/mL in cell type HepG2

VPS24 antibody - N-terminal region (ARP34452_P050) - ARP34452_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CHMP3 Antibody - N-terminal region (ARP75592_P050) - ARP75592_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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