CHMP3

Gene Symbol	CHMP3
Entrez Gene	51652
Alt Symbol	CGI-149, NEDF, VPS24
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 3
Other Description	25.1 protein|CHMP family, member 3|chromatin-modifying protein 3|neuroendocrine differentiation factor|vacuolar protein sorting 24 homolog|vacuolar protein sorting-associated protein 24
Swissprots	Q3ZTS9 Q53SU5 Q9Y3E7 B4DG34 B8ZZX5 Q9NZ51 A8K3W0 B8ZZM0 Q53S71
Accessions	AAX93078 AAY24211 EAW99448 EAW99449 EAW99450 EAW99451 EAW99452 Q9Y3E7 AF151907 AAD34144 AF219226 AAF26737 AK025046 AK025260 AK095433 AK129502 AK290725 BAF83414 AK312353 BAG35273 AK315835 BAF98726 AY364249 AAQ76808 BC004419 AAH04419 BG705423 BI562428 BU192410 DA046087 DA290886 EU446807 ABZ92336 NM_001005753 NP_001005753 NM_001193517 NP_001180446 NM_016079 NP_057163 NR_036454
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location	Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane {ECO:0000305}. Note=Localizes to the midbody of dividing cells.
Tissue Specificity	Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:15632132}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VPS24 full length protein - ab109845 from Abcam Category Protein Source E. coli Species Human

VPS24 Recombinant Protein - H00051652-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human VPS24 Protein - NBP1-72349 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

Human VPS24 protein - orb169548 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

VPS24 protein (His tag) - 80R-1862 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

VPS24 (1-222, His-tag) - AR39043PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

VPS24 (1-222, His-tag) - AR39043PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

VPS24 - H00051652-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VPS24 - H00051652-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VPS24, 1-222aa, Human, His tag, E.coli - 01-2177-24 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

VPS24 fusion protein - Ag7776 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

VPS24 fusion protein - ag7623 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

VPS24, 1-222aa, Recombinant Protein - GWB-P0935L from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human RNF103-CHMP3 - RNF103-CHMP3-1403H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human VPS24, His-tagged - VPS24-3561H from Creative Biomart Category Protein

Recombinant Human VPS24, GST-tagged - VPS24-3671H from Creative Biomart Category Protein Source E.coli Species Human

VPS24 1-222aa - CMB-936 from Reagent Proteins Category Protein Prices $469.00, $889.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

Recombinant Human Charged multivesicular body protein 3(CHMP3) - CSB-YP896506HU CSB-EP896506HU CSB-BP896506HU CSB-MP896506HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

VPS24 (transcript variant 1) - TP320006 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

VPS24 - TP331100 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

VPS24, 1-222aa, Human, His tag, E.coli - ATGP1103 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Vacuolar Protein Sorting 24, Recombinant Protein - MBS145263 from MyBioSource Category Protein Prices $140.00, $205.00, $2,665.00 Sizes 5 µg, 20 µg, 1 mg Source E Coli

VPS24, Recombinant Protein - MBS204629 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 100 µg, 500 µg Source E Coli Species Human

VPS24 Recombinant Protein Antigen - NBP1-89391PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CHMP3-Blocking-Peptide-N-term - BP21033a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Search more