Gene Symbol |
TIAF1
|
Entrez Gene |
9220
|
Alt Symbol |
MAJN, SPR210
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
TGFB1-induced anti-apoptotic factor 1
|
Other Description |
12 kDa TGF-beta-1-induced antiapoptotic factor|TGF-beta-1-induced antiapoptotic factor 1|molecule associated with Jak-3 N-terminal
|
Swissprots |
Q6PEG2 A2RRE2 O95411
|
Accessions |
EAW51180 O95411 AF105277 AAD04172 AK054958 AK126861 BC047669 AAH47669 BC058075 AAH58075 BC131561 AAI31562 NM_004740 NP_004731
|
Function |
Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. {ECO:0000269|PubMed:9918798}.
|
Subcellular Location |
Nucleus {ECO:0000269|PubMed:9918798}.
|
Tissue Specificity |
Not detectable in normal kidney and liver. Up- regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells. {ECO:0000269|PubMed:12829915}.
|