Gene Symbol | TIAF1 |
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Entrez Gene | 9220 |
Alt Symbol | MAJN, SPR210 |
Species | Human |
Gene Type | protein-coding |
Description | TGFB1-induced anti-apoptotic factor 1 |
Other Description | 12 kDa TGF-beta-1-induced antiapoptotic factor|TGF-beta-1-induced antiapoptotic factor 1|molecule associated with Jak-3 N-terminal |
Swissprots | Q6PEG2 A2RRE2 O95411 |
Accessions | EAW51180 O95411 AF105277 AAD04172 AK054958 AK126861 BC047669 AAH47669 BC058075 AAH58075 BC131561 AAI31562 NM_004740 NP_004731 |
Function | Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. {ECO:0000269|PubMed:9918798}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:9918798}. |
Tissue Specificity | Not detectable in normal kidney and liver. Up- regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells. {ECO:0000269|PubMed:12829915}. |
TIAF-1 CRISPR/Cas9 KO Plasmid (h) - sc-408797 from Santa Cruz Biotechnology
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TIAF-1 HDR Plasmid (h) - sc-408797-HDR from Santa Cruz Biotechnology
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TIAF-1 Double Nickase Plasmid (h) - sc-408797-NIC from Santa Cruz Biotechnology
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TIAF-1 Double Nickase Plasmid (h2) - sc-408797-NIC-2 from Santa Cruz Biotechnology
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TIAF-1 CRISPR Activation Plasmid (h) - sc-408797-ACT from Santa Cruz Biotechnology
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TIAF-1 CRISPR Activation Plasmid (h2) - sc-408797-ACT-2 from Santa Cruz Biotechnology
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TIAF-1 Lentiviral Activation Particles (h) - sc-408797-LAC from Santa Cruz Biotechnology
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TIAF-1 Lentiviral Activation Particles (h2) - sc-408797-LAC-2 from Santa Cruz Biotechnology
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TIAF-1 siRNA (h) - sc-76660 from Santa Cruz Biotechnology
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TIAF-1 shRNA Plasmid (h) - sc-76660-SH from Santa Cruz Biotechnology
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TIAF-1 shRNA (h) Lentiviral Particles - sc-76660-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU221441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21338 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21338 from Sigma-Aldrich
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TIAF1 siRNA (Human) - CRH6104 from Cohesion Biosciences
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TIAF1 - MBS8206398 from MyBioSource
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shRNA set against Human TIAF1 (NM_004740.3) - SHH427192 from Creative biogene
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Human TIAF1 siRNA - orb266606 from Biorbyt
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TIAF1 shRNA Plasmid (Human) - CHH6104 from Cohesion Biosciences
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TIAF1 miRNA 3'UTR clone - MiUTR1H-10401 from Creative biogene
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