Gene Symbol | TIAF1 |
---|---|
Entrez Gene | 9220 |
Alt Symbol | MAJN, SPR210 |
Species | Human |
Gene Type | protein-coding |
Description | TGFB1-induced anti-apoptotic factor 1 |
Other Description | 12 kDa TGF-beta-1-induced antiapoptotic factor|TGF-beta-1-induced antiapoptotic factor 1|molecule associated with Jak-3 N-terminal |
Swissprots | Q6PEG2 A2RRE2 O95411 |
Accessions | EAW51180 O95411 AF105277 AAD04172 AK054958 AK126861 BC047669 AAH47669 BC058075 AAH58075 BC131561 AAI31562 NM_004740 NP_004731 |
Function | Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. {ECO:0000269|PubMed:9918798}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:9918798}. |
Tissue Specificity | Not detectable in normal kidney and liver. Up- regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells. {ECO:0000269|PubMed:12829915}. |