| Gene Symbol | TSPAN12 |
|---|---|
| Entrez Gene | 23554 |
| Alt Symbol | EVR5, NET-2, NET2, TM4SF12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tetraspanin 12 |
| Other Description | tetraspan NET-2|tetraspanin-12|transmembrane 4 superfamily member 12|tspan-12 |
| Swissprots | Q549U9 Q8N5Y0 A4D0V8 O95859 B4DRG6 |
| Accessions | AAQ96879 EAL24349 EAW83543 EAW83544 EAW83545 O95859 AF124522 AAD17317 AK299247 BAG61278 AK307161 AK312239 BAG35172 AY358703 AAQ89066 BC031265 AAH31265 BF338835 BI964728 DQ893699 ABM84625 XM_005250239 XP_005250296 XM_011515993 XP_011514295 XM_011515994 XP_011514296 NM_012338 NP_036470 |
| Function | Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. {ECO:0000250, ECO:0000269|PubMed:19211836, ECO:0000269|PubMed:19587294}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |