TSPAN12

Gene Symbol	TSPAN12
Entrez Gene	23554
Alt Symbol	EVR5, NET-2, NET2, TM4SF12
Species	Human
Gene Type	protein-coding
Description	tetraspanin 12
Other Description	tetraspan NET-2|tetraspanin-12|transmembrane 4 superfamily member 12|tspan-12
Swissprots	Q549U9 Q8N5Y0 A4D0V8 O95859 B4DRG6
Accessions	AAQ96879 EAL24349 EAW83543 EAW83544 EAW83545 O95859 AF124522 AAD17317 AK299247 BAG61278 AK307161 AK312239 BAG35172 AY358703 AAQ89066 BC031265 AAH31265 BF338835 BI964728 DQ893699 ABM84625 XM_005250239 XP_005250296 XM_011515993 XP_011514295 XM_011515994 XP_011514296 NM_012338 NP_036470
Function	Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. {ECO:0000250, ECO:0000269|PubMed:19211836, ECO:0000269|PubMed:19587294}.
Subcellular Location	Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TSPAN12 Antibody Blocking Peptide - LS-E17055 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TSPAN12 Antibody Blocking Peptide - LS-E9728 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TSPAN12-Antibody-C-term-Blocking-Peptide - BP8693b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Tetraspanin 12 Blocking Peptide - 33R-2156 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Tetraspanin 12 Blocking Peptide - 33R-2410 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TSPAN12 fusion protein - ag3514 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TSPAN12, GST-tagged - TSPAN12-3455H from Creative Biomart Category Protein Source E.coli Species Human

Tetraspanin-12 (TSPAN12) - TP306943 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Tetraspanin-12 (TSPAN12), Recombinant Protein - MBS1040385 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

TSPAN12 Recombinant Protein Antigen - NBP2-49278PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

TSPAN12 Peptide, Human - M34GP16729H from Creative Peptides Category Peptide Source Synthetic. Species Human

Tetraspanin-12 (TSPAN12), Recombinant Protein - MBS7057982 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Tetraspanin-12 (TSPAN12), Recombinant Protein - MBS7032254 from MyBioSource Category Protein Prices $1,115.00, $2,100.00, $3,310.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Species Human

Tetraspanin-12 (TSPAN12), Recombinant Protein - MBS7084769 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

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