TSPAN12

Gene Symbol TSPAN12
Entrez Gene 23554
Alt Symbol EVR5, NET-2, NET2, TM4SF12
Species Human
Gene Type protein-coding
Description tetraspanin 12
Other Description tetraspan NET-2|tetraspanin-12|transmembrane 4 superfamily member 12|tspan-12
Swissprots Q549U9 Q8N5Y0 A4D0V8 O95859 B4DRG6
Accessions AAQ96879 EAL24349 EAW83543 EAW83544 EAW83545 O95859 AF124522 AAD17317 AK299247 BAG61278 AK307161 AK312239 BAG35172 AY358703 AAQ89066 BC031265 AAH31265 BF338835 BI964728 DQ893699 ABM84625 XM_005250239 XP_005250296 XM_011515993 XP_011514295 XM_011515994 XP_011514296 NM_012338 NP_036470
Function Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. {ECO:0000250, ECO:0000269|PubMed:19211836, ECO:0000269|PubMed:19587294}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

NET-2 (C-20) - sc-243597 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NET-2 (H-25) - sc-133810 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
NET-2 (H-25): sc-133810. Western blot analysis of NET-2 expression in SK-N-MC whole cell lysate.

Anti-TSPAN12 antibody - ab93179 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TSPAN12 antibody (ab93179) at 1/100 dilution + T47D cell line lysate at 35 µg

Anti-TSPAN12 antibody - ab90091 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TSPAN12 antibody (ab90091) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal thymus lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TSPAN12 Antibody (C-Terminus, AP) - LS-C246140 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSPAN12 Antibody (C-Terminus, Biotin) - LS-C246141 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSPAN12 Antibody (C-Terminus, FITC) - LS-C246142 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSPAN12 Antibody (C-Terminus, PE) - LS-C246144 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSPAN12 Antibody (C-Terminus, APC) - LS-C246477 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSPAN12 Antibody (C-Terminus, Azide-free, HRP) - LS-C247925 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSPAN12 Antibody (C-Terminus) - LS-C328870 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TSPAN12 Antibody (aa179-228) - LS-C111131 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TSPAN12 antibody LS-C111131 Western blot of Fetal Thymus lysate.

Anti-TSPAN12 Antibody (aa232-259) - LS-C160262 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with TSPAN12 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-TSPAN12 Antibody (aa185-234) IHC-plus™ - LS-B9720 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TSPAN12 antibody IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9720 concentration 5 ug/ml.

TSPAN12 Antibody - NBP1-91298 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TSPAN12 Antibody [NBP1-91298] - Titration: 0.2-1 ug/ml, Positive Control: Human Thymus.

TSPAN12 Antibody - NBP1-91297 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: TSPAN12 Antibody [NBP1-91297] - HepG2 cell lysate, concentration 0.2-1 ug/ml.

TSPAN12 Antibody - NBP2-13489 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: TSPAN12 Antibody [NBP2-13489] Staining of human testis shows moderate cytoplasmic and membranous positivity in cells in seminiferus ducts.

TSPAN12 Polyclonal Antibody - bs-10425R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-TSPAN12 Polyclonal Antibody, Unconjugated (bs-10425R) at 1:200 followed by conjugation to the secondary antibody and DAB staining\\n

TSPAN12 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-10425R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TSPAN12 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-10425R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TSPAN12 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-10425R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TSPAN12 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-10425R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TSPAN12 Polyclonal Antibody, Cy3 Conjugated - bs-10425R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TSPAN12 Polyclonal Antibody, Cy5 Conjugated - bs-10425R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TSPAN12 Polyclonal Antibody, Cy5.5 Conjugated - bs-10425R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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