| Gene Symbol |
RAC2
|
| Entrez Gene |
5880
|
| Alt Symbol |
EN-7, Gx, HSPC022, p21-Rac2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
|
| Other Description |
Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)|ras-related C3 botulinum toxin substrate 2|small G protein
|
| Swissprots |
P15153 Q9UDJ4
|
| Accessions |
AAB22207 EAW60149 EAW60150 EAW60151 EAW60152 EAW60153 P15153 AF077208 AAD27003 AF498965 AAM21112 AK096924 BC001485 AAH01485 BC018735 BC051899 BI908751 BQ934070 BT006919 AAP35565 CR456555 CAG30441 CU013155 CAK54586 CU013443 CAK54885 DQ893288 ABM84214 DQ896620 ABM87619 EU176461 ABW03912 M29871 AAA36538 XM_006724286 XP_006724349 NM_002872 NP_002863
|
| Function |
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. {ECO:0000269|PubMed:1660188}.
|
| Subcellular Location |
Cytoplasm. Note=Membrane-associated when activated.
|
| Tissue Specificity |
Hematopoietic specific.
|
| Top Pathways |
Sphingolipid signaling pathway, Chemokine signaling pathway, cAMP signaling pathway, Choline metabolism in cancer, Rap1 signaling pathway
|