Gene Symbol | RAC2 |
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Entrez Gene | 5880 |
Alt Symbol | EN-7, Gx, HSPC022, p21-Rac2 |
Species | Human |
Gene Type | protein-coding |
Description | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
Other Description | Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)|ras-related C3 botulinum toxin substrate 2|small G protein |
Swissprots | P15153 Q9UDJ4 |
Accessions | AAB22207 EAW60149 EAW60150 EAW60151 EAW60152 EAW60153 P15153 AF077208 AAD27003 AF498965 AAM21112 AK096924 BC001485 AAH01485 BC018735 BC051899 BI908751 BQ934070 BT006919 AAP35565 CR456555 CAG30441 CU013155 CAK54586 CU013443 CAK54885 DQ893288 ABM84214 DQ896620 ABM87619 EU176461 ABW03912 M29871 AAA36538 XM_006724286 XP_006724349 NM_002872 NP_002863 |
Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. {ECO:0000269|PubMed:1660188}. |
Subcellular Location | Cytoplasm. Note=Membrane-associated when activated. |
Tissue Specificity | Hematopoietic specific. |
Top Pathways | Sphingolipid signaling pathway, Chemokine signaling pathway, cAMP signaling pathway, Choline metabolism in cancer, Rap1 signaling pathway |
Rac 2 CRISPR/Cas9 KO Plasmid (h) - sc-401157 from Santa Cruz Biotechnology
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Rac 2 HDR Plasmid (h) - sc-401157-HDR from Santa Cruz Biotechnology
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Rac 2 Double Nickase Plasmid (h) - sc-401157-NIC from Santa Cruz Biotechnology
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Rac 2 Double Nickase Plasmid (h2) - sc-401157-NIC-2 from Santa Cruz Biotechnology
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Rac 2 CRISPR Activation Plasmid (h) - sc-401157-ACT from Santa Cruz Biotechnology
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Rac 2 CRISPR Activation Plasmid (h2) - sc-401157-ACT-2 from Santa Cruz Biotechnology
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Rac 2 Lentiviral Activation Particles (h) - sc-401157-LAC from Santa Cruz Biotechnology
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Rac 2 Lentiviral Activation Particles (h2) - sc-401157-LAC-2 from Santa Cruz Biotechnology
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Rac 2 siRNA (h) - sc-29461 from Santa Cruz Biotechnology
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Rac 2 shRNA Plasmid (h) - sc-29461-SH from Santa Cruz Biotechnology
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Rac 2 shRNA (h) Lentiviral Particles - sc-29461-V from Santa Cruz Biotechnology
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RAC2 RNAi - H00005880-R01 from Novus Biologicals
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MISSION® esiRNA - EHU120691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1540 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1540 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06717 from Sigma-Aldrich
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RAC2 siRNA (Human) - CRH3970 from Cohesion Biosciences
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RAC2 - MBS8200613 from MyBioSource
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shRNA set against Human RAC2(NM_002872.3) - SHR161178 from Creative biogene
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Human RAC2 siRNA - orb264472 from Biorbyt
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RAC2 shRNA Plasmid (Human) - CHH3970 from Cohesion Biosciences
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RAC2 miRNA 3'UTR clone - MiUTR1H-08589 from Creative biogene
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