Prkcd

Gene Symbol Prkcd
Entrez Gene 18753
Alt Symbol AI385711, D14Ertd420e, PKC[d], PKCdelta, Pkcd
Species Mouse
Gene Type protein-coding
Description protein kinase C, delta
Other Description nPKC-delta|protein kinase C delta type|protein kinase C delta variant IX|protein kinase C, delta IV|protein kinase C, delta V|protein kinase C[d]|tyrosine-protein kinase PRKCD
Swissprots Q9Z333 P28867 Q91V85
Accessions AAF79208 EDL24758 EDL24759 P28867 AB011812 BAA36408 AB201453 BAE93682 AB201454 BAE93683 AB201455 BAE93684 AB201456 BAE93685 AF251036 AAF64316 AK144231 BAE25785 AK161540 BAE36451 AK168768 BAE40604 AK171476 AW122017 AY545076 AAS57795 BC051416 AAH51416 HQ840432 ADX77909 M69042 AAA73056 X60304 CAA42845 XM_006518695 XP_006518758 XM_006518696 XP_006518759 XM_006518697 XP_006518760 XM_006518698 XP_006518761 NM_011103 NP_035233
Function Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death- promoting transcription factor BCLAF1/Btf to trigger BCLAF1- mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Isoform 1 is highly expressed in developing pro- and pre-B-cells and moderately in mature T-cells. Isoform 2 is highly expressed in testis and ovary and at a lower level in thymocytes, brain and kidney.
Top Pathways Fc gamma R-mediated phagocytosis, Inflammatory mediator regulation of TRP channels, Estrogen signaling pathway, Vascular smooth muscle contraction, Chemokine signaling pathway

PKC δ (G-9) - sc-8402 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PKC δ (G-9): sc-8402. Western blot analysis of PKC δ expression in 3611-RF whole cell lysate.

p-PKC δ (Ser 643) - sc-22266 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-PKC δ (Ser 643): sc-22266. Western blot analysis of PKC δ phosphorylation in untreated (A) and PMA-treated (B) RAW 264.7 whole cell lysates.

p-PKC δ (Ser 643) - sc-18370 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-PKC δ (Ser 643)-R: sc-18370-R. Western blot analysis of PKC δ phosphorylation in NIH/3T3 whole cell lysate.

p-PKC δ (Tyr 523) - sc-18371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-PKC δ (Tyr 523): sc-18371. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing cytoplasmic staining of glandular cells.

p-PKC δ (Ser 645) - sc-101777 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of phosphorylated PKC expression in MCF7 whole cell lysate (A,B). Blots were probed with p-PKC (Ser 645): sc-101777 preincubated with its cognate phosphorylated peptide (A) and p-PKC (Ser 645): sc-101777 (B).

Anti-PKC delta antibody - ab4142 from Abcam

Prices $373.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Mouse-Prkcd-Antibody-N-term - AP14629a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Prkcd Antibody (N-term) (Cat. #AP14629a) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Prkcd antibody detected the Prkcd protein (arrow).

Mouse Prkcd Antibody - N-terminal region (OAAB10954) - OAAB10954 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

PKC theta antibody (Ser645) - 70R-34360 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

PKC theta antibody - 70R-34361 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Mouse Prkcd Antibody - abx028187 from Abbexa

Host Rabbit
Clonality Polyclonal

Prkcd antibody (N-term) - STJ44186 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal
Clone RB34865

PKCdelta, Polyclonal Antibody - MBS417042 from MyBioSource

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

PKCdelta, Polyclonal Antibody - MBS417124 from MyBioSource

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Protein Kinase C Delta (PKCd) - PAA433Mu01 from Cloud-clone

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Protein Kinase C Delta (PKCd) - PAA433Mu02 from Cloud-clone

Host Rabbit
Clonality Polyclonal

PKC delta antibody - 70R-50254 from Fitzgerald

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PKC delta antibody - 70R-50253 from Fitzgerald

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Prkcd, Polyclonal Antibody - MBS9209285 from MyBioSource

Prices $155.00, $340.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal

ANTI-MOUSE PRKCD (N-TERM) antibody produced in rabbit - SAB1302542 from Sigma-Aldrich

Prices $336.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-Mouse Prkcd (N-term): <B>Cat. No. SAB1302542</B>: Mouse Prkcd Antibody (N-term) western blot analysis in mouse lung tissue lysates (35 μg/lane).

Mouse Prkcd Antibody - 57-869 from ProSci

Prices $375.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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