Prkcd

Gene Symbol	Prkcd
Entrez Gene	18753
Alt Symbol	AI385711, D14Ertd420e, PKC[d], PKCdelta, Pkcd
Species	Mouse
Gene Type	protein-coding
Description	protein kinase C, delta
Other Description	nPKC-delta|protein kinase C delta type|protein kinase C delta variant IX|protein kinase C, delta IV|protein kinase C, delta V|protein kinase C[d]|tyrosine-protein kinase PRKCD
Swissprots	Q9Z333 P28867 Q91V85
Accessions	AAF79208 EDL24758 EDL24759 P28867 AB011812 BAA36408 AB201453 BAE93682 AB201454 BAE93683 AB201455 BAE93684 AB201456 BAE93685 AF251036 AAF64316 AK144231 BAE25785 AK161540 BAE36451 AK168768 BAE40604 AK171476 AW122017 AY545076 AAS57795 BC051416 AAH51416 HQ840432 ADX77909 M69042 AAA73056 X60304 CAA42845 XM_006518695 XP_006518758 XM_006518696 XP_006518759 XM_006518697 XP_006518760 XM_006518698 XP_006518761 NM_011103 NP_035233
Function	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death- promoting transcription factor BCLAF1/Btf to trigger BCLAF1- mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex
Subcellular Location	Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Isoform 1 is highly expressed in developing pro- and pre-B-cells and moderately in mature T-cells. Isoform 2 is highly expressed in testis and ovary and at a lower level in thymocytes, brain and kidney.
Top Pathways	Fc gamma R-mediated phagocytosis, Inflammatory mediator regulation of TRP channels, Estrogen signaling pathway, Vascular smooth muscle contraction, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® PKCδ Kinase Assay Kit - 7586 from Cell Signaling Technology Category Assay Kit

Protein Kinase C Delta (PKCd), Mouse, ELISA Kit - SEA433Mu from ARP American Research Products Category ELISA Kit Prices $668.00 Sizes 96 t Sensitivity 0.54ng/mL Range 1.56-100ng/mL

Mouse PKCd ELISA Kit - MP0110 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse PKCd(Protein Kinase C Delta) ELISA Kit - E-EL-M0974 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Mouse Protein Kinase C Delta ELISA - E03P0103 from BlueGene Biotech Category ELISA Kit Sensitivity 0.1 ng/mL

ELISA Kit for Protein Kinase C Delta (PKCd) - SEA433Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.54ng/mL. Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

Mouse PKCd(Protein Kinase C Delta) ELISA Kit - E-EL-M0974 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mL Range 0.16~10 ng/mL

Mouse PKCd ELISA Kit - abx154551 from Abbexa Category ELISA Kit Range 1.56 ng/ml - 100 ng/ml

Protein Kinase C Delta (PKCd), Mouse, ELISA Kit - DL-PKCd-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 1.56-100 ng/mL

Mouse PKCd ELISA Kit - abx573864 from Abbexa Category ELISA Kit Sensitivity 0.54 ng/ml Range 1.563 ng/ml - 100 ng/ml

Mouse PKCd ELISA Kit - E065154 from Biobool Category ELISA Kit Sensitivity Typically less than 0.54ng/mL.

Mouse Prkcd ELISA Kit - E087858 from Biobool Category ELISA Kit

PRKCD ELISA Kit (Mouse) (OKCD00660) - OKCD00660 from Aviva Systems Biology Category ELISA Kit Prices $515.00 Sizes 96 wells Sensitivity < 0.54 ng/mL Range 1.56-100 ng/mL

Mouse PKCd ELISA Kit - EMP0110 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse Protein kinase C delta type (PRKCD) ELISA Kit - AE25970MO from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.54 ng/mL Range 1.56-100 ng/mL

Protein Kinase C Delta (PKCd), ELISA Kit - MBS452988 from MyBioSource Category ELISA Kit Prices $395.00, $520.00, $2,275.00, $4,420.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.54ng/mL Range 1.56-100ng/mL

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