Prkcd
| Gene Symbol | Prkcd |
|---|---|
| Entrez Gene | 18753 |
| Alt Symbol | AI385711, D14Ertd420e, PKC[d], PKCdelta, Pkcd |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | protein kinase C, delta |
| Other Description | nPKC-delta|protein kinase C delta type|protein kinase C delta variant IX|protein kinase C, delta IV|protein kinase C, delta V|protein kinase C[d]|tyrosine-protein kinase PRKCD |
| Swissprots | Q9Z333 P28867 Q91V85 |
| Accessions | AAF79208 EDL24758 EDL24759 P28867 AB011812 BAA36408 AB201453 BAE93682 AB201454 BAE93683 AB201455 BAE93684 AB201456 BAE93685 AF251036 AAF64316 AK144231 BAE25785 AK161540 BAE36451 AK168768 BAE40604 AK171476 AW122017 AY545076 AAS57795 BC051416 AAH51416 HQ840432 ADX77909 M69042 AAA73056 X60304 CAA42845 XM_006518695 XP_006518758 XM_006518696 XP_006518759 XM_006518697 XP_006518760 XM_006518698 XP_006518761 NM_011103 NP_035233 |
| Function | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death- promoting transcription factor BCLAF1/Btf to trigger BCLAF1- mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is highly expressed in developing pro- and pre-B-cells and moderately in mature T-cells. Isoform 2 is highly expressed in testis and ovary and at a lower level in thymocytes, brain and kidney. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Inflammatory mediator regulation of TRP channels, Estrogen signaling pathway, Vascular smooth muscle contraction, Chemokine signaling pathway |
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