CCR4

Gene Symbol	CCR4
Entrez Gene	1233
Alt Symbol	CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5
Species	Human
Gene Type	protein-coding
Description	chemokine (C-C motif) receptor 4
Other Description	C-C CKR-4|C-C chemokine receptor type 4|CCR-4|chemokine (C-C) receptor 4
Swissprots	Q9ULY7 Q9ULY6 P51679
Accessions	AAP84352 ABK41942 BAA86965 BAA86966 BAA86967 BAA86968 BAA86969 EAW64440 EAW64441 P51679 AK292674 BAF85363 BC069139 AAH69139 BC071751 AAH71751 BC074935 AAH74935 CD639869 CD640816 NM_005508 NP_005499
Function	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269|PubMed:10466728, ECO:0000269|PubMed:10754297, ECO:0000269|PubMed:16137713, ECO:0000269|PubMed:9169480, ECO:0000269|PubMed:9430724}.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. {ECO:0000269|PubMed:10754297}.
Top Pathways	Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse CCR4 peptide - ab47642 from Abcam Category Peptide

CCR4 Antibody Blocking Peptide - LS-E5605 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCR4 Antibody Blocking Peptide - LS-E10731 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCR4 Antibody Blocking Peptide - LS-E28762 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CCR4 Antibody Blocking Peptide - LS-E28768 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CCR4 Antibody Blocking Peptide - LS-E29009 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CCR4 Antibody Blocking Peptide - LS-E28959 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CCR4 Recombinant Protein - H00001233-P01 from Novus Biologicals Category Protein Species Human

CCR4-Antibody-C-term-Blocking-Peptide - BP18134b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CCR-4 peptide - orb72454 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

CCR4 peptide - orb219037 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

CCR4 Blocking Peptide - 33R-9054 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CCR4 Blocking Peptide - 33R-10931 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

CCR4 Blocking Peptide - abx062068 from Abbexa Category Peptide Species Human, Bovine

CD194 / CCR4 - H00001233-G01 from Acris Antibodies Category Protein Prices $440.00 Sizes 2 µg Species Human

CD194 / CCR4 Control Peptide - AP09937CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg Species Human

CCR4 fusion protein - ag14562 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

CCR4 fusion protein - ag14535 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) - RPB920Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

CCR4 Blocking Peptide - CBP3174 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Bovine

CCR4 Blocking Peptide - CBP3820 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Dog

Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) - RPB920Hu01 from Cloud-clone Category Protein Source E.coli Species Human

CCR4 Blocking Peptide - 3817BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

Recombinant Human CCR4 Protein - H00001233-G01 from Novus Biologicals Category Protein Prices $415.00 Sizes 2 µg Source Wheat Germ Species Human

CCR4 Blocking Peptide - abx161321 from Abbexa Category Peptide Source Synthetic Species Human, Mouse, Dog

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