CCR4

Gene Symbol CCR4
Entrez Gene 1233
Alt Symbol CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5
Species Human
Gene Type protein-coding
Description chemokine (C-C motif) receptor 4
Other Description C-C CKR-4|C-C chemokine receptor type 4|CCR-4|chemokine (C-C) receptor 4
Swissprots Q9ULY7 Q9ULY6 P51679
Accessions AAP84352 ABK41942 BAA86965 BAA86966 BAA86967 BAA86968 BAA86969 EAW64440 EAW64441 P51679 AK292674 BAF85363 BC069139 AAH69139 BC071751 AAH71751 BC074935 AAH74935 CD639869 CD640816 NM_005508 NP_005499
Function High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269|PubMed:10466728, ECO:0000269|PubMed:10754297, ECO:0000269|PubMed:16137713, ECO:0000269|PubMed:9169480, ECO:0000269|PubMed:9430724}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells. {ECO:0000269|PubMed:10754297}.
Top Pathways Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Viral carcinogenesis

CKR-4 (C-20) - sc-6126 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CKR-4 (H-48) - sc-7936 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CKR-4 (G-2) - sc-377357 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CKR-4 (G-2): sc-377357. Western blot analysis of CKR-4 expression in human platelet extract.

CKR-4 (K-14) - sc-32133 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CKR-4 (KH-4F5) - sc-101375 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

CKR-4 (N-19) - sc-32132 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CKR-4 (V-16) - sc-32134 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CCR4 antibody - ab1669 from Abcam

Prices $391.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry using ab1669 on a section of human spleen.

Anti-CCR4 antibody [KH-4F5] - ab59550 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone KH-4F5
Spectral Confocal Microscopy of CHO cells using ab59550 at 1 &microg/106 cells . CHO cells were transiently transfected with an expression vector encoding CCR4. Binding of ab59550 was visualized with a FITC-conjugated secondary antibody (green). Actin filaments are labeled with Alexa Fluor-555 Phalloidin (red). Cell nuclei are stained with DAPI (blue).

Anti-CCR4 antibody - C-terminal - ab173799 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CCR4 antibody - C-terminal (ab173799) at 1/100 dilution + HL60 cell line lysates at 35 µg

Anti-CCR4 Antibody (aa346-360) - LS-C312672 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
CCR4 antibody. IHC(P): Human Tonsil Tissue.

Anti-CCR4 Antibody (Extracellular Domain) IHC-plus™ - LS-B4033 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-CCR4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4033 concentration 5 ug/ml.

Anti-CCR4 Antibody (N-Terminus) IHC-plus™ - LS-A348 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CCR4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CCR4 Antibody (aa8-26, Fab'2) - LS-C83940 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCR4 Antibody (aa8-26) - LS-C83951 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Goat
Clonality Polyclonal

Anti-CCR4 Antibody (N-Terminus) - LS-C88915 from LifeSpan Bioscience

Prices $295.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-CCR4 Antibody - LS-C88916 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CCR4 Antibody - LS-C651 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of CCR4 in A) Daudi and B) NIH 3T3 cell lysate using antibody at 1 ug/ml.

Anti-CCR4 Antibody (aa17-39) - LS-C121142 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CCR4 Antibody (aa8-26) - LS-C122827 from LifeSpan Bioscience

Prices $545.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-CCR4 Antibody (clone 11D79, FITC) - LS-C183817 from LifeSpan Bioscience

Prices $445.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 11D79

Anti-CCR4 Antibody (aa211-260) - LS-C119432 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HUVEC cells, using CCR4 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-CCR4 Antibody (clone 11D80, PerCP) - LS-C183818 from LifeSpan Bioscience

Prices $575.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 11D80

Anti-CCR4 Antibody (clone 11D81, PE) - LS-C183819 from LifeSpan Bioscience

Prices $530.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 11D81

Anti-CCR4 Antibody (aa180-229) - LS-C102829 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CCR4 antibody LS-C102829 Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.
Search more