PKN2

Gene Symbol PKN2
Entrez Gene 5586
Alt Symbol PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7
Species Human
Gene Type protein-coding
Description protein kinase N2
Other Description PKN gamma|cardiolipin-activated protein kinase Pak2|protein kinase C-like 2|protein-kinase C-related kinase 2|serine/threonine-protein kinase N2
Swissprots B4DTP5 Q16513 Q08AF4 B4DVG1 Q9H1W4 D3DT24 B4DQ21
Accessions EAW73161 EAW73162 EAW73163 EAW73164 EAW73165 Q16513 AF118089 AAF22033 AK023692 AK298595 BAG60783 AK300304 BAG62057 AK301066 BAG62673 BC006993 BC029749 AAH29749 BC038832 BC046146 BC062620 AAH62620 BC125199 AAI25200 DA451427 S75548 AAB33346 U33052 AAC50208 XM_005271031 XP_005271088 XM_011541769 XP_011540071 XM_011541770 XP_011540072 XM_011541771 XP_011540073 XM_011541772 XP_011540074 NM_006256 NP_006247
Function PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migr
Subcellular Location Cytoplasm. Nucleus. Membrane {ECO:0000250}. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm.
Tissue Specificity Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:21754995}.
Top Pathways Salmonella infection, PI3K-Akt signaling pathway

PRK2 (D10A10) Rabbit mAb - 8697 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10A10
Western blot analysis of extracts from various cell lines using PRK2 (D10A10) Rabbit mAb.

PRK2 Antibody - 2612 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using PRK2 Antibody.

PRK2 (A-3) - sc-271971 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRK2 (A-3): sc-271971. Western blot analysis of PRK2 expression in calyculin treated HeLa whole cell lysate.

PRK2 (C-18) - sc-6979 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of phosphorylated PRK2 expression in HeLa whole cell lysates. Blots were probed with RK2 (C-18): sc-6979 (A) and p-PRK2 (Thr 816)-R: sc-12891-R preincubated with cognate unphosphorylated (B) and phosphorylated (C) peptide.

PRK2 (C-6) - sc-271526 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRK2 (C-6): sc-271526. Western blot analysis of PRK2 expression in COLO 320DM whole cell lysate.

PRK2 (H-80) - sc-28774 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PRK2 (H-80): sc-28774. Western blot analysis of PRK2 expression in K-562 whole cell lysate.

PRK2 (N-19) - sc-6980 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PRK2 (N-19): sc-6980. Western blot analysis of PRK2 expression in untreated (A) and Calyculin A-treated (B) HeLa whole cell lysates.

p-PRK2 (Thr 816) - sc-12891 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of phosphorylated PRK2 expression in HeLa whole cell lysates. Blots were probed with RK2 (C-18): sc-6979 (A) and p-PRK2 (Thr 816)-R: sc-12891-R preincubated with cognate unphosphorylated (B) and phosphorylated (C) peptide.

Anti-PKN2 antibody - ab96688 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-PKN2 antibody (ab96688) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-PKN2 antibody - ab57427 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57427 PKN2 antibody at 1ug/ml.

Anti-PKN2 antibody - ab116448 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PKN2 antibody (ab116448) at 1 µg/ml + 293T cell lysate at 10 µg

Anti-PKN2 antibody [1D1] - ab119936 from Abcam

Host Mouse
Clonality Monoclonal
Clone 1D1
Anti-PKN2 antibody [1D1] (ab119936) at 1/500 dilution + Recombinant PKN2 protein

Anti-PKN2 antibody [E352] - ab32395 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E352
Anti-PKN2 antibody [E352] (ab32395) at 1/1000 dilution + 10ug 293T cell lysate

Anti-PKN2 antibody [EPR5490] - ab138514 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5490
All lanes : Anti-PKN2 antibody [EPR5490] (ab138514) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : Jurkat cell lysateLane 3 : HeLa cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PKN2 Antibody (N-Terminus) - LS-C17473 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PKN2 Antibody (aa200-250) - LS-C289178 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PKN2 Antibody (aa250-300) - LS-C289179 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PKN2 Antibody - LS-C296120 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PKN2 Antibody (aa605-654) - LS-C145330 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PKN2 antibody LS-C145330 Western blot of 293T Cell lysate. Antibody concentration 1 ug/ml.

Anti-PKN2 Antibody (Biotin) - LS-C299835 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PKN2 Antibody (aa67-312, Biotin) - LS-C297844 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PKN2 Antibody (aa891-940) - LS-C170363 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PKN2 Antibody (aa323-464, Biotin) - LS-C299902 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PKN2 Antibody (aa282-487, Biotin) - LS-C301321 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PKN2 Antibody (FITC) - LS-C302598 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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