PKN2

Gene Symbol	PKN2
Entrez Gene	5586
Alt Symbol	PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7
Species	Human
Gene Type	protein-coding
Description	protein kinase N2
Other Description	PKN gamma|cardiolipin-activated protein kinase Pak2|protein kinase C-like 2|protein-kinase C-related kinase 2|serine/threonine-protein kinase N2
Swissprots	B4DTP5 Q16513 Q08AF4 B4DVG1 Q9H1W4 D3DT24 B4DQ21
Accessions	EAW73161 EAW73162 EAW73163 EAW73164 EAW73165 Q16513 AF118089 AAF22033 AK023692 AK298595 BAG60783 AK300304 BAG62057 AK301066 BAG62673 BC006993 BC029749 AAH29749 BC038832 BC046146 BC062620 AAH62620 BC125199 AAI25200 DA451427 S75548 AAB33346 U33052 AAC50208 XM_005271031 XP_005271088 XM_011541769 XP_011540071 XM_011541770 XP_011540072 XM_011541771 XP_011540073 XM_011541772 XP_011540074 NM_006256 NP_006247
Function	PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migr
Subcellular Location	Cytoplasm. Nucleus. Membrane {ECO:0000250}. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm.
Tissue Specificity	Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:21754995}.
Top Pathways	Salmonella infection, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PKN2 full length protein - ab89860 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human PKN2 protein fragment - ab159208 from Abcam Category Protein Source Wheat germ Species Human

PAK2 Antibody Blocking Peptide - LS-E30260 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PAK2 Antibody Blocking Peptide - LS-E30261 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PAK2 Antibody Blocking Peptide - LS-E9373 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKN2 Antibody Blocking Peptide - LS-E22600 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKN2 Antibody Blocking Peptide - LS-E22601 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAK2 Partial Recombinant Protein - H00005062-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PKN2 Partial Recombinant Protein - H00005586-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PAK2 Protein - P4741 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

PAK2 Blocking Peptide - NBP1-76721PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PAK2 Blocking Peptide - NBP1-76720PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PKN2 Peptide - P2922 from Novus Biologicals Category Peptide Species Human

PAK2 Peptide - P2912 from Novus Biologicals Category Peptide Species Human

PRK2-Antibody-C-term-Blocking-Peptide - BP7939a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Aurora A blocking peptide - GTX29689-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

PAK2 Blocking Peptide - 33R-10761 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

PAK2 Blocking Peptide - 33R-10490 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

PKN2 Blocking Peptide - 33R-9351 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human Protein Kinase N2 Protein - abx068759 from Abbexa Category Protein Source E.coli Species Human

Human Protein Kinase N2 Protein - abx068761 from Abbexa Category Protein Source E.coli Species Human

PAK2 (phospho-Ser20) Blocking Peptide - abx063043 from Abbexa Category Peptide Species Human, Mouse, Rat, Rabbit

PKN2 - H00005586-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PKN2 - H00005586-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PKN2 - P5624 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

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