PKN2
| Gene Symbol | PKN2 |
|---|---|
| Entrez Gene | 5586 |
| Alt Symbol | PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase N2 |
| Other Description | PKN gamma|cardiolipin-activated protein kinase Pak2|protein kinase C-like 2|protein-kinase C-related kinase 2|serine/threonine-protein kinase N2 |
| Swissprots | B4DTP5 Q16513 Q08AF4 B4DVG1 Q9H1W4 D3DT24 B4DQ21 |
| Accessions | EAW73161 EAW73162 EAW73163 EAW73164 EAW73165 Q16513 AF118089 AAF22033 AK023692 AK298595 BAG60783 AK300304 BAG62057 AK301066 BAG62673 BC006993 BC029749 AAH29749 BC038832 BC046146 BC062620 AAH62620 BC125199 AAI25200 DA451427 S75548 AAB33346 U33052 AAC50208 XM_005271031 XP_005271088 XM_011541769 XP_011540071 XM_011541770 XP_011540072 XM_011541771 XP_011540073 XM_011541772 XP_011540074 NM_006256 NP_006247 |
| Function | PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migr |
| Subcellular Location | Cytoplasm. Nucleus. Membrane {ECO:0000250}. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Cleavage furrow. Midbody. Cell junction. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm. |
| Tissue Specificity | Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:21754995}. |
| Top Pathways | Salmonella infection, PI3K-Akt signaling pathway |
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