Gene Symbol | ADSSL1 |
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Entrez Gene | 122622 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | adenylosuccinate synthase like 1 |
Other Description | AMPSase 1|IMP--aspartate ligase 1|M-type adenylosuccinate synthetase|adSS 1|adenylosuccinate synthetase isozyme 1|adenylosuccinate synthetase, basic isozyme|adenylosuccinate synthetase, muscle isozyme |
Swissprots | Q86TT6 Q8N142 Q8N714 |
Accessions | EAW81876 Q8N142 AK054648 AK095921 BAC04649 AK096124 BAG53216 AK096720 BAG53356 AY037159 AAK67646 BC032039 AAH32039 BC047904 AAH47904 BX248286 CAD62614 XM_006720026 XP_006720089 XM_011536412 XP_011534714 XM_011536413 XP_011534715 XM_011536414 XP_011534716 XM_011536415 XP_011534717 NM_152328 NP_689541 NM_199165 NP_954634 |
Function | Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03126, ECO:0000269|PubMed:15786719}. |
Tissue Specificity | Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors. {ECO:0000269|PubMed:15786719}. |
Top Pathways | Purine metabolism, Alanine, aspartate and glutamate metabolism |
AdSS1 CRISPR/Cas9 KO Plasmid (h) - sc-408315 from Santa Cruz Biotechnology
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AdSS1 HDR Plasmid (h) - sc-408315-HDR from Santa Cruz Biotechnology
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AdSS1 Double Nickase Plasmid (h) - sc-408315-NIC from Santa Cruz Biotechnology
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AdSS1 Double Nickase Plasmid (h2) - sc-408315-NIC-2 from Santa Cruz Biotechnology
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AdSS1 CRISPR Activation Plasmid (h) - sc-408315-ACT from Santa Cruz Biotechnology
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AdSS1 CRISPR Activation Plasmid (h2) - sc-408315-ACT-2 from Santa Cruz Biotechnology
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AdSS1 Lentiviral Activation Particles (h) - sc-408315-LAC from Santa Cruz Biotechnology
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AdSS1 Lentiviral Activation Particles (h2) - sc-408315-LAC-2 from Santa Cruz Biotechnology
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AdSS1 siRNA (h) - sc-105046 from Santa Cruz Biotechnology
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AdSS1 shRNA Plasmid (h) - sc-105046-SH from Santa Cruz Biotechnology
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AdSS1 shRNA (h) Lentiviral Particles - sc-105046-V from Santa Cruz Biotechnology
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ADSSL1 RNAi - H00122622-R01 from Novus Biologicals
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ADSSL1 RNAi - H00122622-R02 from Novus Biologicals
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MISSION® esiRNA - EHU157021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2907 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2907 from Sigma-Aldrich
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ADSSL1 siRNA (Human) - CRJ4701 from Cohesion Biosciences
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ADSSL1 - MBS8201608 from MyBioSource
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shRNA set against Human ADSSL1 (NM_199165.1) - SHH232838 from Creative biogene
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shRNA set against Human ADSSL1(NM_152328.3) - SHG044389 from Creative biogene
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shRNA set against Human ADSSL1(NM_199165.1) - SHG044443 from Creative biogene
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Human ADSSL1 siRNA - orb275202 from Biorbyt
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ADSSL1 shRNA Plasmid (Human) - CHJ4701 from Cohesion Biosciences
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ADSSL1 miRNA 3'UTR clone - MiUTR1H-00222 from Creative biogene
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ADSSL1 miRNA 3'UTR clone - MiUTR3H-12474 from Creative biogene
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