IL1B

Gene Symbol IL1B
Entrez Gene 3553
Alt Symbol IL-1, IL1-BETA, IL1F2
Species Human
Gene Type protein-coding
Description interleukin 1, beta
Other Description IL-1 beta|catabolin|interleukin-1 beta|preinterleukin 1 beta|pro-interleukin-1-beta
Swissprots Q53X59 P01584 Q9UCT6 Q7RU01 Q7M4S7 Q96HE5 Q53XX2
Accessions AAA74137 AAM88883 AAX88888 CAA28185 CAD29872 CCA63968 EAW73605 EAW73606 EAW73607 P01584 AB451494 BAG70308 AF043335 AAC03536 AK313983 BC008678 AAH08678 BT007213 AAP35877 CR407679 CAG28607 DQ890673 ABM81599 DQ893854 ABM84780 K02770 AAA36106 M15330 AAA59135 M54933 AAA59136 X02532 CAA26372 X56087 CAA39567 XM_006712496 XP_006712559 NM_000576 NP_000567
Function Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. {ECO:0000269|PubMed:3920526}.
Subcellular Location Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Top Pathways Herpes simplex infection, Tuberculosis, Legionellosis, TNF signaling pathway, Salmonella infection

IL-1β (D3U3E) Rabbit mAb (PE Conjugate) - 13627 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D3U3E
Flow cytometric analysis of THP-1 cells, untreated (blue) or LPS-treated (100 ng/ml, 3 hr; green), using IL-1β (D3U3E) Rabbit mAb (PE Conjugate).

IL-1β (3A6) Mouse mAb - 12242 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 3A6
Western blot analysis of extracts from THP-1 cells, untreated (-) or LPS-treated (100 ng/mL, 3 hr; +), using IL-1β (3A6) Mouse mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

IL-1β (D3U3E) Rabbit mAb - 12703 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3U3E
Western blot analysis of extracts from THP-1 cells, untreated (-) or LPS-treated (100 ng/ml, 3 hr; +), using IL-1β (D3U3E) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Cleaved IL-1β (Asp116) Antibody - 2021 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

IL-1β Antibody - 2022 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

IL-1β (2H12) - sc-130323 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

IL-1β (B122) - sc-12742 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Hamster
Clonality Monoclonal
IL-1β (B122): sc-12742. Western blot analysis of mouse recombinant IL-1β.

IL-1β (C-20) - sc-1250 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of human recombinant IL-1β (A) and mouse recombinant IL-1β (B,C). Antibodies tested include IL-1β (C-20): sc-1250 (A), IL-1β (M-20): sc-1251 (B) and IL-1β (R-20): sc-1252 (C).

IL-1β (E7-2-hILβ) - sc-32294 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-1β (E7-2-hILβ): sc-32294. Western blot analysis of human recombinant IL-1β.

IL-1β (H-153) - sc-7884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-1β (H-153): sc-7884. Western blot analysis of human recombinant IL-1β fusion protein.

IL-1β (AS57) - sc-52771 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IL-1β (AS57): sc-52771. Western blot analysis of human biologically active IL-1β fusion protein.

IL-1β (5C10) - sc-52013 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IL-1β (5C10): sc-52013. Western blot analysis of human recombinant IL-1β fusion protein.

IL-1β (11E5) - sc-52012 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IL-1β (11E5): sc-52012. Western blot analysis of human IL-1β fusion protein.

cleaved IL-1β (h117) - sc-23459 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IL1 beta antibody - ab2105 from Abcam

Prices $403.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab2105 staining IL1 beta in Human monocytes by Flow Cytometry. Cells were fixed with paraformaldehyde and permeabilized with 0.1% saponin in PBS. The sample was incubated with the primary antibody (1/500 in 0.1% saponin + 1% FCS in PBS) for 45 minutes at 4°C. An Alexa Fluor® 488-conjugated Goat anti-rabbit IgG (1/100) was used as the secondary antibody.1 - unstimulated monocytes. 2 - monocytes stimulated with LPS.See Abreview

Anti-IL1 beta antibody - ab9722 from Abcam

Prices $401.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab9722 staining IL1 beta in murine bone marrow-derived macrophages by Immunocytochemistry/ Immunofluorescence. Cells are immortalised murine bone marrow-derived macrophages stably transfected with GFP-LC3 (green) to visualise autophagosomes. The cells were fixed in paraformaldehyde, permeabilised in 0.01% Triton X-100 and then blocked using 5% serum for 1 hour at 20°C. Samples were then incubated with primary antibody at 1/200 for 1 hour at 20°C. The secondary antibody used was a goat anti-rabbit IgG conjugated to Alexa Fluor® 568 (red) used undiluted.See Abreview

Anti-IL1 beta antibody - ab34837 from Abcam

Prices $372.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-IL1 beta antibody - ab82558 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL1 beta antibody (ab82558) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 2 : MOLT4 (Human acute lymphoblastic leukemia cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IL1 beta antibody - ab195991 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-IL1 beta antibody (ab195991) at 1 µg/ml + Human Peripheral Blood Lymphocytes lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-IL1 beta antibody - ab53175 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab53175 at 1/50 dilution staining IL1 beta in human lung carcinoma by Immunohistochemsitry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.

Anti-IL1 beta antibody - ab104279 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IL1 beta antibody (ab104279) at 1 µg/ml + HeLa cell line lysate at 10 µg

Anti-IL1 beta antibody - ab53732 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab53732, at a 1/50 dilution, staining IL1 beta in paraffin embedded human lung carcinoma tissue by Immunohistochemistry in the absence (left image) or presence (rigt image) of the immunising peptide.

Anti-IL1 beta antibody - ab91320 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IL1 beta antibody (ab91320) at 1/100 dilution + NCI-H460 cell line lysate at 35 µg

Anti-IL1 beta antibody - ab26852 from Abcam

Host Chicken
Clonality Polyclonal
Recombinant protein as test antigen. ab26852 at 0.2 ug/ml and Rabbit anti-IgY-HRP as 2nd Ab.

Anti-IL1 beta antibody - ab157763 from Abcam

Host Sheep
Clonality Polyclonal
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