COPS6

Gene Symbol COPS6
Entrez Gene 10980
Alt Symbol CSN6, MOV34-34KD
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 6
Other Description COP9 constitutive photomorphogenic homolog subunit 6|COP9 signalosome complex subunit 6|COP9 subunit 6 (MOV34 homolog, 34 kD)|H_NH0506M12.12|JAB1-containing signalosome subunit 6|MOV34 homolog, 34 kD|SGN6|hVIP|signalosome subunit 6|vpr-interacting protein
Swissprots O15387 Q7L5N1 A4D2A3
Accessions CBF67503 CBU92376 EAL23857 EAW76601 EAW76602 Q7L5N1 AK295237 BAG58230 AK312024 BAG34961 BC002520 AAH02520 BI113801 CB990467 CD367717 DQ891943 ABM82869 DQ894927 ABM85853 U70735 AAD03469 NM_006833 NP_006824
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|Pu
Subcellular Location Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:9520381}.

CSN6 (B-1) - sc-393023 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSN6 (B-1): sc-393023. Western blot analysis of CSN6 expression in SW480 (A), HeLa (B), 3T3-L1 (C) and A-375 (D) whole cell lysates.

CSN6 (C-17) - sc-47965 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN6 (C-17): sc-47965. Western blot analysis of CSN6 expression in rat brain tissue extract.

CSN6 (C-13) - sc-47964 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CSN6 (C-13): sc-47964. Western blot analysis of CSN6 expression in SW480 whole cell lysate.

CSN6 (D-7) - sc-137153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSN6 (D-7): sc-137153. Western blot analysis of CSN6 expression in HeLa (A) and 3T3-L1 (B) whole cell lysates.

CSN6 (H-300) - sc-135205 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CSN6 (H-300): sc-135205. Western blot analysis of CSN6 expression in rat brain (A) and mouse brain (B) tissue extracts.

CSN6 (H-3) - sc-137122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CSN6 (H-3): sc-137122. Western blot analysis of CSN6 expression in HeLa (A) and 3T3-L1 (B) whole cell lysates and rat brain tissue extract (C).

CSN6 (N-18) - sc-47966 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-COPS6 antibody - ab82348 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-COPS6 antibody (ab82348) at 1/50 dilution + NCI-H460 cell line lysates at 35 µg

Anti-COPS6 / CSN6 Antibody (aa201-250) - LS-C116838 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
COPS6 antibody LS-C116838 Western blot of 721_B cell lysate.

Anti-COPS6 / CSN6 Antibody (clone 2H5) - LS-C134034 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 2H5
Immunoperoxidase of monoclonal antibody to COPS6 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 1.5 ug/ml]

Anti-COPS6 / CSN6 Antibody (C-Terminus) - LS-C345570 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of COPS6 Antibody with human Fetal Lung lysate.

Anti-COPS6 / CSN6 Antibody (aa58-327, clone 2H4) - LS-C340612 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 2H4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY COPS6 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-COPS6.

Anti-COPS6 / CSN6 Antibody - LS-C343788 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot: Luminograph of a HeLa S3 cytosol preparation after SDS PAGE followed by blotting onto PVDF membrane and probing with (a) antibody BML-PW8295 and (b) antibody BML-PW8295 pre-absorbed with cognate peptide.

Anti-COPS6 / CSN6 Antibody - LS-C346213 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of A549 cell using COPS6 antibody. Blue: DAPI for nuclear staining.

Anti-COPS6 / CSN6 Antibody (clone 2F5) - LS-C174502 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 2F5
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-COPS6 mouse monoclonal antibody.

Anti-COPS6 / CSN6 Antibody (clone 4E7) - LS-C174568 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 4E7
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-COPS6 mouse monoclonal antibody.

COPS6 Antibody - NBP1-79752 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

COPS6 Antibody - NBP1-91805 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

COPS6 Antibody - H00010980-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: COPS6 Antibody [H00010980-B01] - analysis of COPS6 expression in transfected 293T cell line by COPS6 MaxPab polyclonal antibody. Lane 1: COPS6 transfected lysate (35.97 KDa). Lane 2: Non-transfected lysate.

COPS6 Antibody (2H5) - H00010980-M08 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2H5
Immunohistochemistry-Paraffin: COPS6 Antibody (2H5) [H00010980-M08] - Analysis of monoclonal antibody to COPS6 on formalin-fixed paraffin-embedded human placenta. Antibody concentration 1.5 ug/ml

COPS6 Antibody - H00010980-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

COPS6 Polyclonal Antibody - bs-9120R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-COPS6 antibody produced in rabbit - SAB2107380 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-COPS6: <B>Cat. No. SAB2107380</B>: Western blot analysis of COPS6 with COPS6 (COP9 constitutive photomorphogenic homolog subunit 6, Arabidopsis) antibody, against the middle region of COPS6 (50 μg) antibody at 1.0 μg/mL.

Anti-COPS6 (51-64) antibody produced in rabbit - SAB1105487 from Sigma-Aldrich

Prices $279.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-COPS6 antibody produced in mouse - SAB1408806 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-COPS6: <B>Cat. No. SAB1408806</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~36 kDa using COPS6 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.
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