COPS6

Gene Symbol	COPS6
Entrez Gene	10980
Alt Symbol	CSN6, MOV34-34KD
Species	Human
Gene Type	protein-coding
Description	COP9 signalosome subunit 6
Other Description	COP9 constitutive photomorphogenic homolog subunit 6|COP9 signalosome complex subunit 6|COP9 subunit 6 (MOV34 homolog, 34 kD)|H_NH0506M12.12|JAB1-containing signalosome subunit 6|MOV34 homolog, 34 kD|SGN6|hVIP|signalosome subunit 6|vpr-interacting protein
Swissprots	O15387 Q7L5N1 A4D2A3
Accessions	CBF67503 CBU92376 EAL23857 EAW76601 EAW76602 Q7L5N1 AK295237 BAG58230 AK312024 BAG34961 BC002520 AAH02520 BI113801 CB990467 CD367717 DQ891943 ABM82869 DQ894927 ABM85853 U70735 AAD03469 NM_006833 NP_006824
Function	Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|Pu
Subcellular Location	Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9520381}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human COPS6 full length protein - ab132862 from Abcam Category Protein Source Wheat germ Species Human

Human COPS6 full length protein - ab168076 from Abcam Category Protein Source E. coli Species Human

Human COPS6 peptide - ab92686 from Abcam Category Peptide

Human COPS6 protein fragment - ab161225 from Abcam Category Protein Source Wheat germ Species Human

COPS6 Partial Recombinant Protein - H00010980-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

COPS6 Recombinant Protein - H00010980-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human COPS6 Protein - NBP2-22798 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli Species Human

COPS6-Antibody-Center-Blocking-Peptide - BP2869c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human COPS6 protein - orb191240 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

COPS6 protein (His tag) - 80R-2967 from Fitzgerald Category Protein Prices $375.00 Sizes 100 µg Source E.coli

COPS6 (1-327, His-tag) - AR51085PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

COPS6 (1-327, His-tag) - AR51085PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

COPS6 - H00010980-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

COPS6 - H00010980-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

COPS6 - H00010980-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

COPS6 - H00010980-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

COPS6, 1-327aa, Human, His tag, E.coli - 01-P2261 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

COPS6 fusion protein - ag0331 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human COPS6, His-tagged - COPS6-15905H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human COP9 signalosome complex subunit 6(COPS6) - CSB-YP745336HU CSB-EP745336HU CSB-BP745336HU CSB-MP745336HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

COPS6, 1-327aa, Human, His tag, E.coli (Denatured) - ATGP2261 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 20 µg, 100 µg, 500 µg Species Human

COPS6 - TP300252 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

COPS6 Recombinant Protein Antigen - NBP1-91805PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

COPS6 Peptide, Human - M34GP03503H from Creative Peptides Category Peptide Source Synthetic. Species Human

COPS6 - PAT-82260-1 from Nordic BioSite Category Protein Species Human

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