COPS6

Gene Symbol COPS6
Entrez Gene 10980
Alt Symbol CSN6, MOV34-34KD
Species Human
Gene Type protein-coding
Description COP9 signalosome subunit 6
Other Description COP9 constitutive photomorphogenic homolog subunit 6|COP9 signalosome complex subunit 6|COP9 subunit 6 (MOV34 homolog, 34 kD)|H_NH0506M12.12|JAB1-containing signalosome subunit 6|MOV34 homolog, 34 kD|SGN6|hVIP|signalosome subunit 6|vpr-interacting protein
Swissprots O15387 Q7L5N1 A4D2A3
Accessions CBF67503 CBU92376 EAL23857 EAW76601 EAW76602 Q7L5N1 AK295237 BAG58230 AK312024 BAG34961 BC002520 AAH02520 BI113801 CB990467 CD367717 DQ891943 ABM82869 DQ894927 ABM85853 U70735 AAD03469 NM_006833 NP_006824
Function Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|Pu
Subcellular Location Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:9520381}.

COP9 signalosome complex subunit 6 (COPS6), Human, ELISA Kit - E01C1941 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

COP9 signalosome complex subunit 6, ELISA Kit - MBS280227 from MyBioSource

Category ELISA Kit
Prices $465.00, $790.00, $3,500.00, $6,655.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7208491 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7222317 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7225909 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7221560 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7229496 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7226425 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7229794 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7239293 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7218358 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7215038 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7252432 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

COP9 signalosome complex subunit 6 (COPS6), ELISA Kit - MBS7215331 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human COPS6 ELISA Kit - E080302 from Biobool

Category ELISA Kit
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