Gene Symbol | ALDH8A1 |
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Entrez Gene | 64577 |
Alt Symbol | ALDH12, DJ352A20.2 |
Species | Human |
Gene Type | protein-coding |
Description | aldehyde dehydrogenase 8 family, member A1 |
Other Description | aldehyde dehydrogenase 12|aldehyde dehydrogenase family 8 member A1|aldehyde dehydrogenase family protein |
Swissprots | Q53GT3 O60793 Q9H2A2 Q5TI80 Q24JS9 B7Z521 |
Accessions | EAW47985 EAW47986 Q9H2A2 AF303134 AAG42417 AK074266 AK222848 BAD96568 AK290784 BAF83473 AK298325 BAH12757 BC020849 BC113862 AAI13863 BC114473 AAI14474 BF590409 BX647324 DA635162 XM_006715551 XP_006715614 NM_001193480 NP_001180409 NM_022568 NP_072090 NM_170771 NP_739577 |
Function | Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro). {ECO:0000269|PubMed:11007799}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Tissue Specificity | Highly expressed in adult kidney and liver. Detected at lower levels in fetal liver and kidney. {ECO:0000269|PubMed:11007799}. |
ALDH8A1 CRISPR/Cas9 KO Plasmid (h) - sc-406326 from Santa Cruz Biotechnology
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ALDH8A1 HDR Plasmid (h) - sc-406326-HDR from Santa Cruz Biotechnology
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ALDH8A1 Double Nickase Plasmid (h) - sc-406326-NIC from Santa Cruz Biotechnology
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ALDH8A1 Double Nickase Plasmid (h2) - sc-406326-NIC-2 from Santa Cruz Biotechnology
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ALDH8A1 CRISPR Activation Plasmid (h) - sc-406326-ACT from Santa Cruz Biotechnology
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ALDH8A1 CRISPR Activation Plasmid (h2) - sc-406326-ACT-2 from Santa Cruz Biotechnology
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ALDH8A1 Lentiviral Activation Particles (h) - sc-406326-LAC from Santa Cruz Biotechnology
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ALDH8A1 Lentiviral Activation Particles (h2) - sc-406326-LAC-2 from Santa Cruz Biotechnology
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ALDH8A1 siRNA (h) - sc-95150 from Santa Cruz Biotechnology
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ALDH8A1 shRNA Plasmid (h) - sc-95150-SH from Santa Cruz Biotechnology
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ALDH8A1 shRNA (h) Lentiviral Particles - sc-95150-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU068211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2489 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2489 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07547 from Sigma-Aldrich
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ALDH8A1 siRNA (Human) - CRJ2034 from Cohesion Biosciences
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ALDH8A1 - MBS8225741 from MyBioSource
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ALDH8A1 CRISPR/Cas9 KO Plasmid (h2) - sc-406326-KO-2 from Santa Cruz Biotechnology
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ALDH8A1 HDR Plasmid (h2) - sc-406326-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human ALDH8A1 (NM_022568.3) - SHH234974 from Creative biogene
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ALDH8A1 shRNA Plasmid (Human) - CHJ2034 from Cohesion Biosciences
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ALDH8A1 miRNA 3'UTR clone - MiUTR3H-08478 from Creative biogene
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ALDH8A1 miRNA 3'UTR clone - MiUTR3H-08479 from Creative biogene
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