Gene Symbol | PSKH1 |
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Entrez Gene | 5681 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | protein serine kinase H1 |
Other Description | PSK-H1|serine/threonine-protein kinase H1 |
Swissprots | P11801 Q9NY19 |
Accessions | EAW83185 P11801 AJ272212 CAB91984 AK309272 BC021584 BC037560 BC062616 AAH62616 DA429976 M14504 AAA36519 NM_006742 NP_006733 |
Function | May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. {ECO:0000269|PubMed:12466556}. |
Subcellular Location | Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Cytoplasm. Note=Localized in the brefeldin A- sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes. |
Tissue Specificity | Expressed in all tissues and cell lines tested with the highest level of abundance in testis. {ECO:0000269|PubMed:11087665}. |
PSKH1 (E-9) - sc-514401 from Santa Cruz Biotechnology
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PSKH1 (S-13) - sc-165302 from Santa Cruz Biotechnology
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PSKH1 (V-14) - sc-165303 from Santa Cruz Biotechnology
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PSKH1 (H-90) - sc-292959 from Santa Cruz Biotechnology
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PSKH1 (D-13) - sc-165301 from Santa Cruz Biotechnology
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Anti-PSKH1 antibody - ab135639 from Abcam
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Anti-PSKH1 antibody - ab69993 from Abcam
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Anti-PSKH1 Antibody (Met295) - LS-C192006 from LifeSpan Bioscience
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Anti-PSKH1 Antibody (C-Terminus) - LS-C151331 from LifeSpan Bioscience
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Anti-PSKH1 Antibody (aa261-310) - LS-C118777 from LifeSpan Bioscience
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Anti-PSKH1 Antibody (N-Terminus) - LS-C99062 from LifeSpan Bioscience
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Anti-PSKH1 Antibody (aa1-218) - LS-C185888 from LifeSpan Bioscience
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PSKH1 Antibody - NBP1-32668 from Novus Biologicals
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PSKH1 Antibody - NBP2-19981 from Novus Biologicals
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Anti-PSKH1 (N-term C3) antibody produced in rabbit - SAB1300823 from Sigma-Aldrich
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Anti-PSKH1 (N-term L9) antibody produced in rabbit - SAB1300826 from Sigma-Aldrich
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Anti-PSKH1 (N-term) antibody produced in rabbit - SAB1300401 from Sigma-Aldrich
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Anti-PSKH1 (N-term H70) antibody produced in rabbit - SAB1300825 from Sigma-Aldrich
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Anti-KPSH1 antibody produced in rabbit - SAB4502432 from Sigma-Aldrich
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Anti-PSKH1 antibody produced in rabbit - HPA053927 from Sigma-Aldrich
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PSKH1-Antibody-N-term-H70 - AP7179c from Abgent, a WuXi AppTec company
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PSKH1 Antibody - N-terminal region (Phospho-H70) (OAAB16950) - OAAB16950 from Aviva Systems Biology
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PSKH1 Antibody (OAAF02137) - OAAF02137 from Aviva Systems Biology
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PSKH1 antibody - orb73706 from Biorbyt
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PSKH1 antibody (OAGA00584) - OAGA00584 from Aviva Systems Biology
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