| Gene Symbol | PSKH1 |
|---|---|
| Entrez Gene | 5681 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein serine kinase H1 |
| Other Description | PSK-H1|serine/threonine-protein kinase H1 |
| Swissprots | P11801 Q9NY19 |
| Accessions | EAW83185 P11801 AJ272212 CAB91984 AK309272 BC021584 BC037560 BC062616 AAH62616 DA429976 M14504 AAA36519 NM_006742 NP_006733 |
| Function | May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing. {ECO:0000269|PubMed:12466556}. |
| Subcellular Location | Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Cytoplasm. Note=Localized in the brefeldin A- sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes. |
| Tissue Specificity | Expressed in all tissues and cell lines tested with the highest level of abundance in testis. {ECO:0000269|PubMed:11087665}. |