| Gene Symbol |
NOSIP
|
| Entrez Gene |
51070
|
| Alt Symbol |
CGI-25
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nitric oxide synthase interacting protein
|
| Other Description |
eNOS-interacting protein|nitric oxide synthase-interacting protein
|
| Swissprots |
Q96FD2 Q9Y314
|
| Accessions |
EAW52501 EAW52502 EAW52503 Q9Y314 AF132959 AAD27734 AK092444 AK291535 BAF84224 AK300720 BAG62395 BC009299 AAH09299 BC010077 AAH10077 BC011249 AAH11249 BC047314 BE826708 DB470916 HQ448656 ADQ33134 XM_005258964 XP_005259021 XM_006723235 XP_006723298 XM_011527015 XP_011525317 XM_011527016 XP_011525318 XM_011527017 XP_011525319 NM_001270960 NP_001257889 NM_015953 NP_057037
|
| Function |
Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. {ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle.
|
| Tissue Specificity |
Expressed in heart, brain and lung. Present in endothelial cells (at protein level). {ECO:0000269|PubMed:11149895}.
|
![Western Blot: NOSIP Overexpression Lysate (Adult Normal) [NBL1-13722] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NOSIP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8913_NOSIP%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-13722-img0002.jpg)