Gene Symbol | NOSIP |
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Entrez Gene | 51070 |
Alt Symbol | CGI-25 |
Species | Human |
Gene Type | protein-coding |
Description | nitric oxide synthase interacting protein |
Other Description | eNOS-interacting protein|nitric oxide synthase-interacting protein |
Swissprots | Q96FD2 Q9Y314 |
Accessions | EAW52501 EAW52502 EAW52503 Q9Y314 AF132959 AAD27734 AK092444 AK291535 BAF84224 AK300720 BAG62395 BC009299 AAH09299 BC010077 AAH10077 BC011249 AAH11249 BC047314 BE826708 DB470916 HQ448656 ADQ33134 XM_005258964 XP_005259021 XM_006723235 XP_006723298 XM_011527015 XP_011525317 XM_011527016 XP_011525318 XM_011527017 XP_011525319 NM_001270960 NP_001257889 NM_015953 NP_057037 |
Function | Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. {ECO:0000269|PubMed:11149895, ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:16135813}. |
Subcellular Location | Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle. |
Tissue Specificity | Expressed in heart, brain and lung. Present in endothelial cells (at protein level). {ECO:0000269|PubMed:11149895}. |
NOSIP CRISPR/Cas9 KO Plasmid (h) - sc-404767 from Santa Cruz Biotechnology
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NOSIP HDR Plasmid (h) - sc-404767-HDR from Santa Cruz Biotechnology
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NOSIP Double Nickase Plasmid (h) - sc-404767-NIC from Santa Cruz Biotechnology
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NOSIP Double Nickase Plasmid (h2) - sc-404767-NIC-2 from Santa Cruz Biotechnology
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NOSIP CRISPR Activation Plasmid (h) - sc-404767-ACT from Santa Cruz Biotechnology
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NOSIP CRISPR Activation Plasmid (h2) - sc-404767-ACT-2 from Santa Cruz Biotechnology
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NOSIP Lentiviral Activation Particles (h) - sc-404767-LAC from Santa Cruz Biotechnology
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NOSIP Lentiviral Activation Particles (h2) - sc-404767-LAC-2 from Santa Cruz Biotechnology
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NOSIP siRNA (h) - sc-45708 from Santa Cruz Biotechnology
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NOSIP shRNA Plasmid (h) - sc-45708-SH from Santa Cruz Biotechnology
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NOSIP shRNA (h) Lentiviral Particles - sc-45708-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU029011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15418 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15418 from Sigma-Aldrich
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NOSIP siRNA (Human) - CRH9493 from Cohesion Biosciences
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shRNA set against Human NOSIP (NM_015953.4) - SHH353792 from Creative biogene
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NOSIP shRNA Plasmid (Human) - CHH9493 from Cohesion Biosciences
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NOSIP miRNA 3'UTR clone - MiUTR3H-15600 from Creative biogene
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