| Gene Symbol | ASIP |
|---|---|
| Entrez Gene | 434 |
| Alt Symbol | AGSW, AGTI, AGTIL, ASP, SHEP9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | agouti signaling protein |
| Other Description | agouti signaling protein, nonagouti homolog|agouti switch protein|agouti-signaling protein|nonagouti homolog |
| Swissprots | P42127 Q3SXL2 |
| Accessions | AAA89208 AAB61247 EAW76282 P42127 AY805393 BC104238 AAI04239 BC104239 AAI04240 XM_005260412 XP_005260469 XM_011528820 XP_011527122 XM_011528821 XP_011527123 XM_011528822 XP_011527124 XM_011528823 XP_011527125 NM_001672 NP_001663 |
| Function | Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin. |
| Top Pathways | Melanogenesis |