ASIP

Gene Symbol	ASIP
Entrez Gene	434
Alt Symbol	AGSW, AGTI, AGTIL, ASP, SHEP9
Species	Human
Gene Type	protein-coding
Description	agouti signaling protein
Other Description	agouti signaling protein, nonagouti homolog|agouti switch protein|agouti-signaling protein|nonagouti homolog
Swissprots	P42127 Q3SXL2
Accessions	AAA89208 AAB61247 EAW76282 P42127 AY805393 BC104238 AAI04239 BC104239 AAI04240 XM_005260412 XP_005260469 XM_011528820 XP_011527122 XM_011528821 XP_011527123 XM_011528822 XP_011527124 XM_011528823 XP_011527125 NM_001672 NP_001663
Function	Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Subcellular Location	Secreted.
Tissue Specificity	Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
Top Pathways	Melanogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ASIP protein fragment - ab157919 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Recombinant Human ASIP Protein - H00000434-Q01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

APG5 Recombinant Protein - GTX48089-PRO from GeneTex Category Protein Prices $329.00 Sizes 50 μg Source E. coli Species Human

ATG5 Recombinant Protein - GTX48090-PRO from GeneTex Category Protein Prices $299.00 Sizes 50 μg Source E. coli Species Human

ropporin 1-like Protein - GTX111917-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

ASPA protein (His tag) - 80R-2165 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

Agouti-signaling protein (ASP) - H00000434-Q01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

ASIP fusion protein - ag16357 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ASIP fusion protein - Ag17080 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Apobec 1 Complementation Factor (ACF) - RPA426Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Complement Component 3 (C3) - RPA861Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Agouti-signaling protein(ASIP) - CSB-YP002212HU CSB-EP002212HU CSB-BP002212HU CSB-MP002212HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Agouti-signaling protein (ASIP) - MBS949280 from MyBioSource Category Protein Prices $1,215.00, $1,215.00, $1,670.00, $1,670.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Agouti-signaling protein (ASP) - TP322654 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ASIP Recombinant Protein Antigen - NBP2-14323PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human ASIP/Agouti Protein, CF - 9094-AG from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Human embryonic kidney cell, HEK293-derived His23-Cys132 Species Human

ASIP Peptide, Human - M34GP01045H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Mouse ASIP/Agouti Protein, CF - 9619-AG from Novus Biologicals Category Protein Prices $329.00 Sizes 50 µg

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