ASIP

Gene Symbol ASIP
Entrez Gene 434
Alt Symbol AGSW, AGTI, AGTIL, ASP, SHEP9
Species Human
Gene Type protein-coding
Description agouti signaling protein
Other Description agouti signaling protein, nonagouti homolog|agouti switch protein|agouti-signaling protein|nonagouti homolog
Swissprots P42127 Q3SXL2
Accessions AAA89208 AAB61247 EAW76282 P42127 AY805393 BC104238 AAI04239 BC104239 AAI04240 XM_005260412 XP_005260469 XM_011528820 XP_011527122 XM_011528821 XP_011527123 XM_011528822 XP_011527124 XM_011528823 XP_011527125 NM_001672 NP_001663
Function Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Subcellular Location Secreted.
Tissue Specificity Expressed in adipose tissue, testis, ovary and heart and at lower levels in liver, kidney and foreskin.
Top Pathways Melanogenesis

ASP CRISPR/Cas9 KO Plasmid (h) - sc-409591 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ASP HDR Plasmid (h) - sc-409591-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ASP Double Nickase Plasmid (h) - sc-409591-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ASP Double Nickase Plasmid (h2) - sc-409591-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ASP CRISPR Activation Plasmid (h) - sc-409591-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ASP CRISPR Activation Plasmid (h2) - sc-409591-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ASP Lentiviral Activation Particles (h) - sc-409591-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ASP Lentiviral Activation Particles (h2) - sc-409591-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ASP siRNA (h) - sc-39289 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ASP shRNA Plasmid (h) - sc-39289-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ASP shRNA (h) Lentiviral Particles - sc-39289-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN3598 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3598 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00229 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00229

ASIP siRNA (Human) - CRH0313 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ASIP - MBS8214480 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ASIP (NM_001672.2) - SHH241502 from Creative biogene

Category siRNA
Species Reactivities Human

Human ASIP siRNA - orb260815 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ASIP shRNA Plasmid (Human) - CHH0313 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ASIP miRNA 3'UTR clone - MiUTR1H-00635 from Creative biogene

Species Reactivities Human
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