GRHL3

Gene Symbol	GRHL3
Entrez Gene	57822
Alt Symbol	SOM, TFCP2L4, VWS2
Species	Human
Gene Type	protein-coding
Description	grainyhead-like 3 (Drosophila)
Other Description	grainyhead-like protein 3 homolog|sister of mammalian grainyhead|sister-of-mammalian grainyhead|transcription factor CP2-like 4|transcription factor hSOM1
Swissprots	G3XAF0 Q5TH78 Q8N407 B2RCL1 Q8TE85 A2A297 Q86Y06
Accessions	EAW95120 EAW95121 EAW95122 EAW95123 Q8TE85 AK074386 BAB85067 AK315164 BAG37608 AL137763 CAB70911 AY231160 AAO67370 AY231161 BC036890 AAH36890 BU848928 DA714132 EU446877 ABZ92406 XM_011541869 XP_011540171 XM_011541870 XP_011540172 NM_001195010 NP_001181939 NM_021180 NP_067003 NM_198173 NP_937816 NM_198174 NP_937817
Function	Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establis
Subcellular Location	Nucleus {ECO:0000269|PubMed:21081122}.
Tissue Specificity	Expressed in brain, colon, pancreas, placenta and kidney. Isoform 1 is expressed in lung and tonsil. Isoform 2 is prostate-specific. {ECO:0000269|PubMed:12549979}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GRHL3 protein fragment - ab163659 from Abcam Category Protein Source Wheat germ Species Human

GRHL3 Antibody Blocking Peptide - LS-E4251 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRHL3 Antibody Blocking Peptide - LS-E14280 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRHL3 Partial Recombinant Protein - H00057822-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GRHL3-Antibody-N-term-Blocking-Peptide - BP16526b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GRHL3 Blocking Peptide - 33R-8499 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GRHL3 Blocking Peptide - 33R-2394 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GRHL3 / SOM - H00057822-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GRHL3 / SOM - H00057822-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GRHL3 fusion protein - Ag11560 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

GRHL3 fusion protein - ag11449 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human GRHL3, His-tagged - GRHL3-13525H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Grainyhead-like protein 3 homolog(GRHL3) - CSB-YP844730HU CSB-EP844730HU CSB-BP844730HU CSB-MP844730HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GRHL3 / SOM (transcript variant 3) - TP307857 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

GRHL3 / SOM (N-term HIS tag, transcript variant 3) - TP760712 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

GRHL3 Peptide, Human - M34GP06644H from Creative Peptides Category Peptide Source Synthetic. Species Human

Grainyhead-like protein 3 homolog (GRHL3), Recombinant Protein - MBS1420058 from MyBioSource Category Protein Prices $1,420.00, $1,420.00, $1,650.00, $1,650.00, $2,405.00, $2,405.00, $2,850.00, $2,850.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

GRHL3 Recombinant Protein Antigen - NBP2-57087PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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