GRHL3
| Gene Symbol | GRHL3 |
|---|---|
| Entrez Gene | 57822 |
| Alt Symbol | SOM, TFCP2L4, VWS2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | grainyhead-like 3 (Drosophila) |
| Other Description | grainyhead-like protein 3 homolog|sister of mammalian grainyhead|sister-of-mammalian grainyhead|transcription factor CP2-like 4|transcription factor hSOM1 |
| Swissprots | G3XAF0 Q5TH78 Q8N407 B2RCL1 Q8TE85 A2A297 Q86Y06 |
| Accessions | EAW95120 EAW95121 EAW95122 EAW95123 Q8TE85 AK074386 BAB85067 AK315164 BAG37608 AL137763 CAB70911 AY231160 AAO67370 AY231161 BC036890 AAH36890 BU848928 DA714132 EU446877 ABZ92406 XM_011541869 XP_011540171 XM_011541870 XP_011540172 NM_001195010 NP_001181939 NM_021180 NP_067003 NM_198173 NP_937816 NM_198174 NP_937817 |
| Function | Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establis |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:21081122}. |
| Tissue Specificity | Expressed in brain, colon, pancreas, placenta and kidney. Isoform 1 is expressed in lung and tonsil. Isoform 2 is prostate-specific. {ECO:0000269|PubMed:12549979}. |
GRHL3 CRISPR/Cas9 KO Plasmid (h) - sc-404946 from Santa Cruz Biotechnology
|
||||||||
GRHL3 HDR Plasmid (h) - sc-404946-HDR from Santa Cruz Biotechnology
|
||||||||
GRHL3 Double Nickase Plasmid (h) - sc-404946-NIC from Santa Cruz Biotechnology
|
||||||||
GRHL3 Double Nickase Plasmid (h2) - sc-404946-NIC-2 from Santa Cruz Biotechnology
|
||||||||
GRHL3 CRISPR Activation Plasmid (h) - sc-404946-ACT from Santa Cruz Biotechnology
|
||||||||
GRHL3 CRISPR Activation Plasmid (h2) - sc-404946-ACT-2 from Santa Cruz Biotechnology
|
||||||||
GRHL3 Lentiviral Activation Particles (h) - sc-404946-LAC from Santa Cruz Biotechnology
|
||||||||
GRHL3 Lentiviral Activation Particles (h2) - sc-404946-LAC-2 from Santa Cruz Biotechnology
|
||||||||
GRHL3 siRNA (h) - sc-78890 from Santa Cruz Biotechnology
|
||||||||
GRHL3 shRNA Plasmid (h) - sc-78890-SH from Santa Cruz Biotechnology
|
||||||||
GRHL3 shRNA (h) Lentiviral Particles - sc-78890-V from Santa Cruz Biotechnology
|
||||||||
GRHL3 RNAi - H00057822-R03 from Novus Biologicals
|
||||||||
GRHL3 RNAi - H00057822-R02 from Novus Biologicals
|
||||||||
GRHL3 RNAi - H00057822-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU064401 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN9673 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9673 from Sigma-Aldrich
|
||||||||
GRHL3 siRNA (Human) - CRJ1687 from Cohesion Biosciences
|
||||||||
GRHL3 - MBS8209550 from MyBioSource
|
||||||||
shRNA set against Human GRHL3 (NM_198174.2) - SHH307706 from Creative biogene
|
||||||||
Human GRHL3 siRNA - orb272188 from Biorbyt
|
||||||||
GRHL3 shRNA Plasmid (Human) - CHJ1687 from Cohesion Biosciences
|
||||||||
GRHL3 miRNA 3'UTR clone - MiUTR3H-09915 from Creative biogene
|
||||||||
GRHL3 miRNA 3'UTR clone - MiUTR3H-09916 from Creative biogene
|
||||||||
GRHL3 miRNA 3'UTR clone - MiUTR3H-09917 from Creative biogene
|