Gene Symbol | RNASEH1 |
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Entrez Gene | 246243 |
Alt Symbol | H1RNA, RNH1 |
Species | Human |
Gene Type | protein-coding |
Description | ribonuclease H1 |
Other Description | RNase H1|ribonuclease H type II |
Swissprots | O60857 O60930 Q6FHD4 O60523 Q5U0C1 B3KQU4 Q57Z93 |
Accessions | AAX82026 ADP90574 ADP90575 ADP90576 ADP90577 ADP90578 ADP90579 ADP90580 ADP90581 ADP90582 ADP90583 ADP90584 ADP90585 ADP90586 ADP90587 ADP90588 ADP90589 ADP90590 ADP90591 ADP90592 ADP90593 ADP90594 ADP90595 ADP90596 ADP90597 ADP90598 ADP90599 ADP90600 ADP90601 ADP90602 ADP90603 ADP90604 ADP90605 ADP90606 ADP90607 ADP90608 ADP90609 ADP90610 ADP90611 ADP90612 ADP90613 EAX01061 O60930 AF039652 AAC09261 AF048994 AAC78563 AF048995 AAC78564 AJ224117 CAA11835 AK075490 BAG52156 AK096913 BAG53396 BC002973 AAH02973 BI553044 BT019670 AAV38476 CR541820 CAG46619 DA532761 DA612116 DQ892597 ABM83523 DQ895824 ABM86750 HG493504 HG493505 HG493506 HG493507 HG493508 XR_244873 XR_922665 XR_922666 XR_922667 XR_922668 XR_922669 XR_922670 XR_922671 XR_922672 XR_922673 XR_922674 NM_001286834 NP_001273763 NM_001286837 NP_001273766 NM_002936 NP_002927 |
Function | Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). {ECO:0000269|PubMed:10497183, ECO:0000269|PubMed:21700224}. |
Subcellular Location | Cytoplasm {ECO:0000305}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | DNA replication |
Human RNase H1 full length protein - ab153634 from Abcam
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Human RNase H1 protein fragment - ab153635 from Abcam
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RNH1 Antibody Blocking Peptide - LS-E1673 from LifeSpan Bioscience
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RNH1 Antibody Blocking Peptide - LS-E21137 from LifeSpan Bioscience
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RNH1 Antibody Blocking Peptide - LS-E21136 from LifeSpan Bioscience
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Ribonuclease Inhibitor Partial Recombinant Protein - H00006050-Q01 from Novus Biologicals
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Recombinant Human RNase H1 Protein - H00246243-P01 from Novus Biologicals
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Recombinant Human RNase H1 Protein - H00246243-Q01 from Novus Biologicals
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Ribonuclease Inhibitor Recombinant Protein - H00006050-P01 from Novus Biologicals
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Recombinant E. coli Ribonuclease Inhibitor Protein - NBP1-72417 from Novus Biologicals
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E. coli RNASEH1 protein - orb169199 from Biorbyt
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RNASEH1 Blocking Peptide - 33R-2790 from Fitzgerald
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RNH1 Blocking Peptide - 33R-5147 from Fitzgerald
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RNH1 Blocking Peptide - 33R-7876 from Fitzgerald
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RNASEH1 - H00246243-P01 from Acris Antibodies
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RNASEH1 - H00246243-Q01-10 from Acris Antibodies
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RNASEH1 - H00246243-Q01-25 from Acris Antibodies
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Recombinant Human RNase H1 - 230-00668-10 from RayBiotech
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Recombinant Human RNase H1 - 230-00668-50 from RayBiotech
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Recombinant Human RNase H1 - 230-00668-100 from RayBiotech
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Ribonuclease H1 E.Coli Recombinant - 228-12315-1 from RayBiotech
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Recombinant Ribonuclease H1 E.Coli - 228-12315-2 from RayBiotech
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Recombinant Ribonuclease H1 E.Coli - 228-12315-3 from RayBiotech
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RNASEH1 fusion protein - Ag7990 from Proteintech Group
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Recombinant Human RNASEH1 protein, His-tagged - RNASEH1-4892H from Creative Biomart
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