RNASEH1
| Gene Symbol | RNASEH1 |
|---|---|
| Entrez Gene | 246243 |
| Alt Symbol | H1RNA, RNH1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribonuclease H1 |
| Other Description | RNase H1|ribonuclease H type II |
| Swissprots | O60857 O60930 Q6FHD4 O60523 Q5U0C1 B3KQU4 Q57Z93 |
| Accessions | AAX82026 ADP90574 ADP90575 ADP90576 ADP90577 ADP90578 ADP90579 ADP90580 ADP90581 ADP90582 ADP90583 ADP90584 ADP90585 ADP90586 ADP90587 ADP90588 ADP90589 ADP90590 ADP90591 ADP90592 ADP90593 ADP90594 ADP90595 ADP90596 ADP90597 ADP90598 ADP90599 ADP90600 ADP90601 ADP90602 ADP90603 ADP90604 ADP90605 ADP90606 ADP90607 ADP90608 ADP90609 ADP90610 ADP90611 ADP90612 ADP90613 EAX01061 O60930 AF039652 AAC09261 AF048994 AAC78563 AF048995 AAC78564 AJ224117 CAA11835 AK075490 BAG52156 AK096913 BAG53396 BC002973 AAH02973 BI553044 BT019670 AAV38476 CR541820 CAG46619 DA532761 DA612116 DQ892597 ABM83523 DQ895824 ABM86750 HG493504 HG493505 HG493506 HG493507 HG493508 XR_244873 XR_922665 XR_922666 XR_922667 XR_922668 XR_922669 XR_922670 XR_922671 XR_922672 XR_922673 XR_922674 NM_001286834 NP_001273763 NM_001286837 NP_001273766 NM_002936 NP_002927 |
| Function | Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). {ECO:0000269|PubMed:10497183, ECO:0000269|PubMed:21700224}. |
| Subcellular Location | Cytoplasm {ECO:0000305}. |
| Tissue Specificity | Ubiquitous. |
| Top Pathways | DNA replication |
RNase H1 CRISPR/Cas9 KO Plasmid (h) - sc-402850 from Santa Cruz Biotechnology
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RNase H1 HDR Plasmid (h) - sc-402850-HDR from Santa Cruz Biotechnology
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RNase H1 Double Nickase Plasmid (h) - sc-402850-NIC from Santa Cruz Biotechnology
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RNase H1 Double Nickase Plasmid (h2) - sc-402850-NIC-2 from Santa Cruz Biotechnology
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RNase H1 CRISPR Activation Plasmid (h) - sc-402850-ACT from Santa Cruz Biotechnology
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RNase H1 CRISPR Activation Plasmid (h2) - sc-402850-ACT-2 from Santa Cruz Biotechnology
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RNase H1 Lentiviral Activation Particles (h) - sc-402850-LAC from Santa Cruz Biotechnology
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RNase H1 Lentiviral Activation Particles (h2) - sc-402850-LAC-2 from Santa Cruz Biotechnology
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RNase H1 siRNA (h) - sc-106515 from Santa Cruz Biotechnology
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RNase H1 shRNA Plasmid (h) - sc-106515-SH from Santa Cruz Biotechnology
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RNase H1 shRNA (h) Lentiviral Particles - sc-106515-V from Santa Cruz Biotechnology
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Ribonuclease Inhibitor RNAi - H00006050-R08 from Novus Biologicals
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Ribonuclease Inhibitor RNAi - H00006050-R03 from Novus Biologicals
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Ribonuclease Inhibitor RNAi - H00006050-R02 from Novus Biologicals
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RNase H1 RNAi - H00246243-R01 from Novus Biologicals
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Ribonuclease Inhibitor RNAi - H00006050-R04 from Novus Biologicals
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Ribonuclease Inhibitor RNAi - H00006050-R01 from Novus Biologicals
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Ribonuclease Inhibitor RNAi - H00006050-R07 from Novus Biologicals
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Ribonuclease Inhibitor RNAi - H00006050-R06 from Novus Biologicals
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Ribonuclease Inhibitor RNAi - H00006050-R05 from Novus Biologicals
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MISSION® esiRNA - EHU106741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18352 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18352 from Sigma-Aldrich
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RNASEH1 siRNA (Human) - CRJ6620 from Cohesion Biosciences
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RNASEH1 - MBS8217631 from MyBioSource
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