| Gene Symbol |
DLG2
|
| Entrez Gene |
1740
|
| Alt Symbol |
PPP1R58, PSD-93, PSD93, chapsyn-110
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
discs, large homolog 2 (Drosophila)
|
| Other Description |
channel-associated protein of synapse-110|channel-associated protein of synapses, 110kDa|discs large 2|discs, large homolog 2, chapsyn-110|disks large homolog 2|postsynaptic density protein PSD-93|protein phosphatase 1, regulatory subunit 58
|
| Swissprots |
Q15700 B7WNY8 Q59G57 Q68CQ8 Q5H9Q4 F8W9V6 Q6ZTA8
|
| Accessions |
CCQ43111 EAW75093 EAW75094 EAW75095 Q15700 AB209252 BAD92489 AK094585 AK125151 BAC86064 AK125152 BAC86065 AK126776 BAC86685 AK127150 BAC86854 AK294375 BAH11750 AK295094 BAH11970 AK295624 BAH12131 AK299778 BAH13126 AK299797 BAH13132 BC104969 BC110844 BC143964 BC156216 AAI56217 BC172464 AAI72464 BM678399 BX537627 BX648386 CR749820 CAH18680 CR933674 CAI45970 DA778233 DC303204 KJ535093 AHW56732 U32376 AAB04949 XM_005273806 XP_005273863 XM_005273810 XP_005273867 XM_005273811 XP_005273868 XM_006718438 XP_006718501 XM_011544778 XP_011543080 XM_011544779 XP_011543081 XM_011544780 XP_011543082 XM_011544781 XP_011543083 XM_011544782 XP_011543084 XM_011544783 XP_011543085 XM_011544784 XP_011543086 XM_011544785 XP_011543087 XM_011544786 XP_011543088 XM_011544787 XP_011543089 XM_011544788 XP_011543090 NM_001142699 NP_001136171 NM_001142700 NP_001136172 NM_001142702 NP_001136174 NM_001206769 NP_001193698 NM_001300983 NP_001287912 NM_001364 NP_001355
|
| Function |
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250|UniProtKB:Q63622}; Lipid-anchor {ECO:0000250|UniProtKB:Q63622}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:Q63622}. Cell junction, synapse {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:Q63622}. Cell projection, axon {ECO:0000250|UniProtKB:Q63622}. Note=Concentrated in soma and postsynaptic density of a subset of neurons. {ECO:0000250|UniProtKB:Q63622}.
|
| Top Pathways |
Hippo signaling pathway
|