DLG2

Gene Symbol DLG2
Entrez Gene 1740
Alt Symbol PPP1R58, PSD-93, PSD93, chapsyn-110
Species Human
Gene Type protein-coding
Description discs, large homolog 2 (Drosophila)
Other Description channel-associated protein of synapse-110|channel-associated protein of synapses, 110kDa|discs large 2|discs, large homolog 2, chapsyn-110|disks large homolog 2|postsynaptic density protein PSD-93|protein phosphatase 1, regulatory subunit 58
Swissprots Q15700 B7WNY8 Q59G57 Q68CQ8 Q5H9Q4 F8W9V6 Q6ZTA8
Accessions CCQ43111 EAW75093 EAW75094 EAW75095 Q15700 AB209252 BAD92489 AK094585 AK125151 BAC86064 AK125152 BAC86065 AK126776 BAC86685 AK127150 BAC86854 AK294375 BAH11750 AK295094 BAH11970 AK295624 BAH12131 AK299778 BAH13126 AK299797 BAH13132 BC104969 BC110844 BC143964 BC156216 AAI56217 BC172464 AAI72464 BM678399 BX537627 BX648386 CR749820 CAH18680 CR933674 CAI45970 DA778233 DC303204 KJ535093 AHW56732 U32376 AAB04949 XM_005273806 XP_005273863 XM_005273810 XP_005273867 XM_005273811 XP_005273868 XM_006718438 XP_006718501 XM_011544778 XP_011543080 XM_011544779 XP_011543081 XM_011544780 XP_011543082 XM_011544781 XP_011543083 XM_011544782 XP_011543084 XM_011544783 XP_011543085 XM_011544784 XP_011543086 XM_011544785 XP_011543087 XM_011544786 XP_011543088 XM_011544787 XP_011543089 XM_011544788 XP_011543090 NM_001142699 NP_001136171 NM_001142700 NP_001136172 NM_001142702 NP_001136174 NM_001206769 NP_001193698 NM_001300983 NP_001287912 NM_001364 NP_001355
Function Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250|UniProtKB:Q63622}; Lipid-anchor {ECO:0000250|UniProtKB:Q63622}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:Q63622}. Cell junction, synapse {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:Q63622}. Cell projection, axon {ECO:0000250|UniProtKB:Q63622}. Note=Concentrated in soma and postsynaptic density of a subset of neurons. {ECO:0000250|UniProtKB:Q63622}.
Top Pathways Hippo signaling pathway

Phospho-PSD93 (Tyr340) Antibody - 2930 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from rat brain, either sham-operated, 15 min ischemia followed by 4 h reperfusion, or 15 min ischemia only, using Phospho-PSD93 (Tyr340) Antibody (upper) or PSD95 Antibody (lower).

PSD93 Antibody - 9445 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from rat and mouse brain using PSD93 Antibody.

PSD-93 (N-20) - sc-12233 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PSD-93 (N-20): sc-12233. Western blot analysis of PSD-93 expression in SK-N-SH (A), IMR-32 (B) and HeLa (C) whole cell lysates.

PSD-93 (L-20) - sc-12234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PSD93 (phospho S28) antibody - ab104682 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-PSD93 antibody - ab2930 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunolocalization of PSD-93 in rat cerebellum using ab2930.

Anti-PSD93 antibody - ab12097 from Abcam

Prices $384.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
ICC/IF image of ab12097 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal donkey serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab12097 at 10µg/ml overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 donkey anti- goat (ab150133) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-PSD93 antibody - ab135961 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PSD93 antibody (ab135961) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-PSD93 antibody [EPR8740] - ab151721 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8740
All lanes : Anti-PSD93 antibody [EPR8740] (ab151721) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : SH-SY5Y cell lysateLane 3 : Jurkat cell lysateLane 4 : Human astrocytoma cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-PSD93 antibody [S18-30] - ab94588 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30

Anti-DLG2 / PSD93 Antibody (aa614-648) - LS-C344268 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of tissue lysates from mouse brain and rat brain (from left to right) with DLG2 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.

Anti-DLG2 / PSD93 Antibody - LS-C22097 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DLG2 / PSD93 Antibody (aa352-366) - LS-C79099 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DLG2 / PSD93 Antibody (aa1-852) - LS-C123227 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DLG2 / PSD93 Antibody (clone S18-30) - LS-C153136 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30

Anti-DLG2 / PSD93 Antibody (aa1-852, clone S18-30, Atto 488) - LS-C230822 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30

Anti-DLG2 / PSD93 Antibody (aa1-852, clone S18-30, Atto 565) - LS-C230823 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30

Anti-DLG2 / PSD93 Antibody (aa1-852, clone S18-30, Atto 594) - LS-C230824 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30

Anti-DLG2 / PSD93 Antibody (aa1-852, clone S18-30, Atto 655) - LS-C230825 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30

Anti-DLG2 / PSD93 Antibody (aa1-852, clone S18-30, Atto 633) - LS-C230826 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30

Anti-DLG2 / PSD93 Antibody (aa1-852, clone S18-30) - LS-C109022 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30
Western blot analysis of Chapsyn-110 in rat brain membrane lysates using a 1:1000 dilution of DLG2 / PSD93 antibody.

Anti-DLG2 / PSD93 Antibody (N-Terminus) - LS-C40416 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
DLG2 / PSD93 antibody LS-C40416 Western blot of Jurkat lysate.

Anti-DLG2 / PSD93 Antibody (aa1-852, clone S18-30, Atto 700) - LS-C230828 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30

Anti-DLG2 / PSD93 Antibody (aa1-852, clone S18-30, APC) - LS-C230829 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30

Anti-DLG2 / PSD93 Antibody (aa1-852, clone S18-30, AP) - LS-C230830 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S18-30
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