DLG2

Gene Symbol DLG2
Entrez Gene 1740
Alt Symbol PPP1R58, PSD-93, PSD93, chapsyn-110
Species Human
Gene Type protein-coding
Description discs, large homolog 2 (Drosophila)
Other Description channel-associated protein of synapse-110|channel-associated protein of synapses, 110kDa|discs large 2|discs, large homolog 2, chapsyn-110|disks large homolog 2|postsynaptic density protein PSD-93|protein phosphatase 1, regulatory subunit 58
Swissprots Q15700 B7WNY8 Q59G57 Q68CQ8 Q5H9Q4 F8W9V6 Q6ZTA8
Accessions CCQ43111 EAW75093 EAW75094 EAW75095 Q15700 AB209252 BAD92489 AK094585 AK125151 BAC86064 AK125152 BAC86065 AK126776 BAC86685 AK127150 BAC86854 AK294375 BAH11750 AK295094 BAH11970 AK295624 BAH12131 AK299778 BAH13126 AK299797 BAH13132 BC104969 BC110844 BC143964 BC156216 AAI56217 BC172464 AAI72464 BM678399 BX537627 BX648386 CR749820 CAH18680 CR933674 CAI45970 DA778233 DC303204 KJ535093 AHW56732 U32376 AAB04949 XM_005273806 XP_005273863 XM_005273810 XP_005273867 XM_005273811 XP_005273868 XM_006718438 XP_006718501 XM_011544778 XP_011543080 XM_011544779 XP_011543081 XM_011544780 XP_011543082 XM_011544781 XP_011543083 XM_011544782 XP_011543084 XM_011544783 XP_011543085 XM_011544784 XP_011543086 XM_011544785 XP_011543087 XM_011544786 XP_011543088 XM_011544787 XP_011543089 XM_011544788 XP_011543090 NM_001142699 NP_001136171 NM_001142700 NP_001136172 NM_001142702 NP_001136174 NM_001206769 NP_001193698 NM_001300983 NP_001287912 NM_001364 NP_001355
Function Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000250|UniProtKB:Q63622}; Lipid-anchor {ECO:0000250|UniProtKB:Q63622}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:Q63622}. Cell junction, synapse {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:Q63622}. Cell projection, axon {ECO:0000250|UniProtKB:Q63622}. Note=Concentrated in soma and postsynaptic density of a subset of neurons. {ECO:0000250|UniProtKB:Q63622}.
Top Pathways Hippo signaling pathway

PSD-93 CRISPR/Cas9 KO Plasmid (h) - sc-405011 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-93 HDR Plasmid (h) - sc-405011-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-93 Double Nickase Plasmid (h) - sc-405011-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-93 Double Nickase Plasmid (h2) - sc-405011-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-93 CRISPR Activation Plasmid (h) - sc-405011-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-93 CRISPR Activation Plasmid (h2) - sc-405011-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-93 Lentiviral Activation Particles (h) - sc-405011-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-93 Lentiviral Activation Particles (h2) - sc-405011-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSD-93 siRNA (h) - sc-36321 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PSD-93 shRNA Plasmid (h) - sc-36321-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PSD-93 shRNA (h) Lentiviral Particles - sc-36321-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PSD93 RNAi - H00283225-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® siRNA - SIHK0611 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0612 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0613 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1926 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1926 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DLG2 siRNA (Human) - CRH1208 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PSD93 RNAi - H00001740-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

DLG2 - MBS8210125 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DLG2 (NM_001364.3) - SHH278493 from Creative biogene

Category siRNA
Species Reactivities Human

DLG2 shRNA Plasmid (Human) - CHH1208 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DLG2 miRNA 3'UTR clone - MiUTR4H-TG02756 from Creative biogene

Species Reactivities Human
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