PSPC1

Gene Symbol PSPC1
Entrez Gene 55269
Alt Symbol PSP1
Species Human
Gene Type protein-coding
Description paraspeckle component 1
Other Description paraspeckle protein 1
Swissprots Q8WXE8 Q9NV36 Q8WXF1 Q5JTQ3 Q8NCZ9
Accessions EAX08232 EAX08233 EAX08234 Q8WXF1 AF448795 AAL59601 AF449627 AAL59602 AK001817 BAA91924 AK090873 AK301554 BAG63050 AL834505 CAD39162 BC014184 AAH14184 BM981042 BP225439 BQ685330 CA425205 CB214993 CR457272 CAG33553 CX759783 DA644474 DC396174 DQ892679 ABM83605 DQ895922 ABM86848 XM_006719844 XP_006719907 XM_011535137 XP_011533439 XM_011535138 XP_011533440 XM_011535139 XP_011533441 XM_011535140 XP_011533442 XM_011535141 XP_011533443 XM_011535142 XP_011533444 XM_011535143 XP_011533445 XR_941616 XR_941617 XR_941619 NM_001042414 NP_001035879 NR_003272 NR_044998
Function Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. {ECO:0000250, ECO:0000269|PubMed:22416126}.
Subcellular Location Nucleus, nucleolus. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus speckle. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.
Tissue Specificity Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. {ECO:0000269|PubMed:11790299}.

PSPC1 CRISPR/Cas9 KO Plasmid (h) - sc-401728 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSPC1 HDR Plasmid (h) - sc-401728-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSPC1 Double Nickase Plasmid (h) - sc-401728-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSPC1 Double Nickase Plasmid (h2) - sc-401728-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSPC1 CRISPR Activation Plasmid (h) - sc-401728-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSPC1 CRISPR Activation Plasmid (h2) - sc-401728-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSPC1 Lentiviral Activation Particles (h) - sc-401728-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSPC1 Lentiviral Activation Particles (h2) - sc-401728-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PSPC1 siRNA (h) - sc-76279 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PSPC1 shRNA Plasmid (h) - sc-76279-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PSPC1 shRNA (h) Lentiviral Particles - sc-76279-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PSPC1 RNAi - H00055269-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU152941 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17640 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17640 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PSPC1 siRNA (Human) - CRJ0610 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PSPC1 (NM_001042414.2) - SHH385652 from Creative biogene

Category siRNA
Species Reactivities Human

Human PSPC1 siRNA - orb271111 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PSPC1 shRNA Plasmid (Human) - CHJ0610 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PSPC1 miRNA 3'UTR clone - MiUTR3H-12419 from Creative biogene

Species Reactivities Human
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